Analysis of urinary ACR,Alpha 1-MG,and NGAL in the diagnosis of disease outcome in patients with early diabetic nephropathy
Objective:To explore the diagnostic value of urinary albumin/creatinine ratio(ACR),alpha 1-microglobulin(α1-MG),and neutrophil gelatinase-associated lipocalin(NGAL)in early diabetic nephropathy.Method:Eighty-five patients with early diabetic nephropathy admitted to our hospital from October 2021 to December 2022 were selected as the study group,and 46 healthy subjects in the same period were selected as the control group.The levels of ACR,α1-MG,and NGAL before treatment were compared between the two groups.In addition,latex immunoturbidimetry was used to detect the above indexes in patients with different disease outcomes before and 2 months after treatment,and the ROC curve was used to analyze the diagnostic value of urine ACR,α1-MG,and NGAL indexes in detecting adverse outcomes of early diabetic nephropathy.Results:Urinary ACR,α1-MG,and NGAL levels in the study group were higher than those in the control group,and urinary ACR,α1-MG,and NGAL levels in the adverse outcome group were higher than those in the good outcome group after 2-months treatment,with statistical significance(P<0.05).ROC curve analysis showed that the area under the adverse outcome curve(AUC)in the diagnosis of early diabetic nephropathy by ACR,α1-MG,and NGAL was 0.998,0.916,and 0.906,with high sensitivity and specificity(P<0.05).Conclusion:Urine ACR,α1-MG,and NGAL indexes have certain predictive values for the outcome of patients with early diabetic nephropathy.
万方数据
维普
