Expression and clinical significance of CK19,Ki67 and galectin-3 in papillary thyroid carcinoma
Objective:To explore the expression of cytokeratin 19(CK19),Ki67 and galectin-3 in papillary thyroid carcinoma(PTC)and their relationship with pathological features.Methods:The clinical data of 68 PTC patients admitted to the hospital from January 2021 to December 2023 were collected.The positive expression rates of CK19,Ki67 and galectin-3 in cancer tissues and adjacent tissues were detected by immunohistochemistry.The relationship between the three indexes and the patients'pathological features was analyzed.Results:The positive expression rates of CK19,Ki67 and galectin-3 in PTC tissues were significantly higher than those in adjacent tissues(P<0.05).There were statistically significant differences in the positive expression rates of CK19 and Ki67 in cancer tissues of PTC patients with different tumor diameters,number of lesions,differentiation types,and clinical stages(P<0.05).Conclusion:The positive expression rates of CK19,Ki67 and galectin-3 in cancer tissues of PTC patients are high,and the positive expressions of CK19 and Ki67 are correlated with tumor size,quantity,differentiation degree,and pathological staging.
万方数据
维普
