摘要
目的:回顾性分析妊娠期糖尿病(GDM)胰岛素抵抗(IR)与血清铁蛋白(SF)水平动态变化的关联性.方法:选取 2022 年 12 月至 2023 年 12 月期间于本院进行产检的 67 例妊娠期糖尿病(GDM)孕妇纳入观察组;另选取同期于本院进行产检的 53 例糖耐量正常孕妇为对照组.观察对比两组孕早、中、晚期FPG、2h PG、Hb、HbA1c、SF、HOMA-IR指数以及观察组SF水平和FPG、2h PG、Hb、HbA1c、HOMA-IR相关性.结果:同组孕妇孕早、中、晚期FPG、2h PG、Hb、HbA1c指标均呈上升趋势,但比较差异无统计学意义(P＞0.05).观察组的孕早、中、晚期FPG、2h PG、Hb、HbA1c均比对照组显著提高(P＜0.05).同组孕妇孕早、中、晚期SF水平均呈上升趋势,但比较差异无统计学意义(P＞0.05).观察组的孕早、中、晚期SF水平均比对照组显著提高(P＜0.05).同组孕妇孕早、中、晚期HOMA-IR指数均呈上升趋势,但比较差异无统计学意义(P＞0.05).观察组的孕早、中、晚期HOMA-IR指数均比对照组显著提高(P＜0.05).观察组SF水平分别和FPG、2h PG、Hb、HbA1c水平以及HOMA-IR指数进行相关性分析,均呈正相关,差异均具备统计学意义(P＜0.05).结论:GDM患者孕早、中、晚期的SF水平升高,与HOMA-IR指数程度呈正相关,SF水平与GDM的多个关键病理生理过程也存在密切相关性,SF水平有潜力成为诊断GDM的重要指标之一.
Abstract
Objective:To retrospectively analyze the relationship between insulin resistance(IR)and serum ferritin(SF)levels in gestational diabetes mellitus(GDM).Methods:67 pregnant women with gestational diabetes mellitus(GDM)who underwent antenatal examination in our hospital from December 2022 to December 2023 were included in the observation group;Another 53 pregnant women with normal glucose tolerance were selected as control group.The FPG,2h PG,Hb,HbA1c,SF and HOMA-IR indices of the two groups in the first,second and third trimester of pregnancy were observed and compared,as well as the correlation between SF level and FPG,2h PG,Hb,HbA1c and HOMA-IR of the observation group.Results:The indexes of FPG,2h PG,Hb and HbA1c in the first,middle and third trimester of pregnant women in the same group showed an increasing trend,but there was no statistical significance(P>0.05).FPG,2h PG,Hb and HbA1c in the observation group were significantly higher than those in the control group in the first,middle and third trimester of pregnancy(P<0.05).SF levels in the first,middle and third trimesters of pregnancy in the same group showed an increasing trend,but there was no statistical significance(P>0.05).SF levels in early,middle and late pregnancy in observation group were significantly higher than those in control group(P<0.05).HOMA-IR index of women in the same group showed an increasing trend in early,middle and late pregnancy,but there was no statistical significance(P>0.05).HOMA-IR index of early,middle and late pregnancy in observation group was significantly higher than that in control group(P<0.05).Correlation analysis was conducted between SF level of the observation group and FPG,2h PG,Hb,HbA1c level and HOMA-IR index,respectively,and all were positively correlated with statistically significant differences(P<0.05).Conclusion:The increase of SF level in the early,middle and late pregnancy of GDM patients is positively correlated with HOMA-IR index,and SF level is also closely correlated with several key pathophysiological processes of GDM.SF level has the potential to become one of the important indicators for the diagnosis of GDM.
维普
万方数据