Study on the therapeutic effect of budesonide suspension combined with ceftriaxone sodium on children with bronchopneumonia
Objective:To investigate the therapeutic effect of inhaled budesonide suspension combined with ceftriaxone sodium on children with bronchial pneumonia.Methods:The clinical data of 120 children with bronchial pneumonia treated in our hospital from September 2022 to January 2024 were retrospectively collected.The children were divided into a control group(n=58)treated with intravenous infusion of ceftriaxone sodium 20-80 mg·kg-1 and an observation group(n=62)treated with additional nebulization inhalation of budesonide suspension 0.2 mg based on the control group.Both groups were treated for 1 week.The clinical efficacy and symptom disappearance time of the two groups were analyzed and compared.Before and after treatment,forced vital capacity(FVC),peak expiratory flow(PEF),forced expiratory volume in one second(FEV1),forced expiratory volume in five seconds(FEV5),forced expiratory volume in ten seconds(FEV10),FEV1),FEV1/FVC,the levels of Procalcitonin(PCT),Soluble intercellular cell adhesion molecule-1(sICAM-1),Soluble interleukin-2 receptor(sIL-2R),and Soluble triggering receptor expressed on myeloid cells-1(sTREM-1)were measured using the enzyme-linked immunosorbent assay(ELISA)and chemiluminescent immunoassay(CLIA)methods,respectively.The incidence of adverse reactions in the two groups was analyzed and compared.Results:The total effective rate of observation group was significantly higher than that of control group(P<0.05).The disappearance time of lung rales,wheezing,shortness of breath and cough in observation group was significantly shorter than that in control group(P<0.05).After treatment,PEF,FVC,FEV1 and FEV1/FVC in observation group were significantly higher than those in control group(P<0.05).After treatment,the levels of PCT,sICAM-1,sIL-2R and sTREM-1 in observation group were significantly lower than those in control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Inhalation of budesonide suspension combined with ceftriaxone sodium can improve the therapeutic effect,improve lung function,alleviate clinical symptoms and reduce inflammation in children with bronchial pneumonia,with high safety.
Budesonide suspension for inhalationCeftriaxone sodiumBronchopneumoniaClinical effectLung function
万方数据
维普
