Clinical effects of endoscopic titanium clip combined with norepinephrine spray on coagulation status,inflammatory factors,and complications in patients with peptic ulcer bleeding
Clinical effects of endoscopic titanium clip combined with norepinephrine spray on coagulation status,inflammatory factors,and complications in patients with peptic ulcer bleeding
Objective:To explore the clinical effects of endoscopic titanium clip combined with norepinephrine spray on coagulation status,inflammatory factors,and complications in patients with peptic ulcer bleeding.Methods:A total of 60 patients with peptic ulcer bleeding confirmed in the hospital were enrolled and randomly divided into a basic group(n=30,endoscopic titanium clip)and a combination group(n=30,endoscopic titanium clip combined with norepinephrine spray)between December 2022 and March 2024.All patients were treated for 12 weeks.Before and at 3 days after treatment,the levels of activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(Fbg),and thrombin time(TT)were detected by automatic coagulometer,the levels of serum C-reactive protein(CRP),tumor necrosis factor(TNF)-α,and interleukin(IL)-6 were detected by enzyme-linked immunosorbent assay.The hemostatic effect in the two groups was compared.After 1 month of follow-up,the quality of life in the two groups was compared,and the occurrence of complications in the two groups was recorded.Results:After 3 days of treatment,APTT,PT,TT,CRP,TNF-α,and IL-6 were decreased,while Fbg was increased in both groups,and the above indexes were better in the combination group than the basic group(P<0.05).The immediate hemostasis rate and 72 hours hemostasis rate in the combination group were higher than those in the basic group(P<0.05).After 1 month of follow-up,the quality of life in the combination group was significantly better(P<0.05).There was no significant difference in the incidence of complications between the combination group and the basic group(6.67%vs 13.33%,P>0.05).Conclusion:Endoscopic titanium clip combined with norepinephrine spray can improve coagulation status and reduce levels of inflammatory factors in patients with peptic ulcer bleeding,which has good safety.
维普
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