Correlation analysis of serum TC and HDL-C expression levels with the degree of coronary artery lesions in patients with ST segment elevation myocardial infarction
Objective:Study on ST-segment elevation myocardial infarction(ST-segment elevation myocardial infarction,ST-segment elevation myocardial infarction,ST-segment elevation myocardial infarction,ST-segment elevation myocardial infarction,The expression of serum Total cholesterol(TC)and High Density lipoprotein cholesterol(HDL-C)in patients with STEMI and their relationship with the degree of coronary artery disease.Methods:Data of 75 healthy subjects who underwent physical examination in our hospital from January 2019 to May 2023 were selected and included in the control group.Data of 75 SREMI patients treated in our hospital during the same period were selected and included in the observation group.The levels of TC and HDL-C were detected.STEMI patients were divided into mild group(24 cases)and severe group(51 cases)according to the degree of coronary artery disease.The baseline data of the two groups were analyzed and compared.To investigate the relationship between serum TC,HDL-C and the degree of coronary artery disease in STEMI patients.Results:Compared with the control group,TC in observation group was significantly increased and HDL-C was significantly decreased(P<0.05).There were no significant differences in gender,age,body mass index and underlying diseases between mild group and severe group(P>0.05).Compared with mild group,Hcy and TC in severe group were significantly increased,and HDL-C was significantly decreased(P<0.05).Logistic regression analysis showed that the degree of coronary lesions in STEMI patients may be related to the high expression of Hcy,the high expression of TC and the low expression of HDL-C(P<0.05).The risk of severe coronary lesions in STEMI patients with high TC expression and low HDL-C expression was 43.646 times higher than that with low TC expression and high HDL-C expression,and the synergistic effect was 3.553 times greater than the sum of the two effects alone(SI=3.553).Conclusion:High expression of TC and low expression of HDL-C may be risk factors for severe coronary artery disease in STEMI patients.
ST-segment elevation myocardial infarctionTotal cholesterolHigh density lipoprotein cholesterolDegree of coronary artery disease
万方数据
维普
