Effect of budesonide combined with NAC oxidation-driven nebulization on the therapeutic efficacy and blood gas indicators of AECOPD patients
Objective:To explore the therapeutic effect of budesonide combined with N-acetylcysteine(NAC)oxidation-driven nebulization on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and its impact on blood gas parameters.Methods:Sixty-six patients with AECOPD in our hospital from January 2020 to December 2023 were randomly divided into two groups(n=33).The control group received NAC oxidation-driven atomization treatment(3 mL each time,twice one day,oxygen flow 4 mL·min-1,20 min each time).The experimental group received budesonide inhalation(1 mg,twice one day)based on the control group.Both groups were treated for 2 weeks.The curative effects of the two groups were compared.The arterial partial pressure(PaO2),carbon dioxide partial pressure(PaCO2),and oxygen saturation(SaO2)were detected by a blood gas analyzer before and after treatment.The serum interleukin-6(IL-6)level was measured by enzyme-linked immunosorbent assay.The levels of procalcitonin(PCT)and C reactive protein(CRP)were detected by immunoturbidimetry.The incidence of complications in the two groups was statistically analyzed and compared.Results:The total effective rate of the experimental group was 96.97%,which was higher than that of the control group(81.82%)(P<0.05).The PaO2 and SaO2 of the patients in the experimental group were higher than those in the control group after treatment,while the PaCO2 was lower than that in the control group(P<0.05).The levels of IL-6,PCT,and CRP in the experimental group after treatment were significantly lower than those in the control group(p<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Budesonide combined with NAC oxidation-driven atomization can improve the clinical efficacy of AECOPD patients,and can effectively improve the blood gas index level.
Chronic obstructive pulmonary diseaseAcute exacerbation periodBudesonideN-acetylcysteineBlood gas indicators
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维普
