Diagnostic value of chemiluminescence and nucleic acid detection for hepatitis B virus in suspected hepatitis B population
Objective:To explore the diagnostic value of chemiluminescence and nucleic acid detection methods for hepatitis B virus in suspected hepatitis B patients.Methods:Sixty suspected hepatitis B patients who were treated in our hospital from December 31,2020 to December 31,2023 were selected as the research subjects.All subjects were tested for hepatitis B virus using chemiluminescence and nucleic acid detection methods after admission.Using the results of liver biopsy as the"gold standard",compare the diagnostic results and efficacy of chemiluminescence and nucleic acid detection methods for the diagnosis of hepatitis B virus alone and in combination.Results:The results of liver biopsy showed that 35 cases were positive and 25 cases were negative among 60 suspected hepatitis B patients.According to the chemiluminescence test,25 cases were positive.According to nucleic acid testing,24 cases were positive.According to the joint diagnosis results,34 cases were positive.The sensitivity and accuracy of the combined diagnosis of chemiluminescence and nucleic acid detection were 88.57%and 88.33%,significantly higher than those of chemiluminescence alone(sensitivity of 65.71%and accuracy of 76.67%)and nucleic acid detection(sensitivity of 60.00%and accuracy of 71.67%).The missed diagnosis rate of the combined detection was 11.43%,significantly lower than the 34.29%of chemiluminescence and 40.00%of nucleic acid detection(P<0.05).Conclusion:The combination of chemiluminescence and nucleic acid detection can improve the accuracy of hepatitis B virus diagnosis in blood samples from suspected hepatitis B patients.
Hepatitis BHepatitis B virusChemiluminescence methodNucleic acid detection methodDiagnostic value
万方数据
维普
