Effect analysis of Montelukast sodium combined with budesonide in the treatment of children with asthmatic bronchitis
Objective:To investigate the effects of aerosol inhalation of Montelukast sodium combined with glucocorticoids in pediatric asthmatic bronchitis(PAB).Methods:80 children with PAB admitted to our hospital from March 2020 to March 2023 were selected as the study objects.The children were randomly divided into control group and study group,40 cases in each group.The control group was treated with budesonide aerosol inhalation,while the study group was treated with montelukast sodium on the basis of the control group.Clinical efficacy,symptom resolution time,inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),white blood cell count(WBC),Leukotriene B4(LTB4),blood gas indexes(arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide in artery(PaCO2)and adverse reactions were analyzed and compared between the two groups.Results:The total effective rate of the study group was significantly higher than that of the control group(P<0.05).The disappearance time of asthma,cough and lung moist rales in the study group were significantly shorter than those in the control group(P<0.05).After treatment,the levels of IL-6,PCT,CRP,ESR,WBC and LTB4 in the study group were significantly lower than those in the control group(P<0.05).PaO2 in the study group was higher than that before treatment,and PaCO2 was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion:Montelukast sodium combined with budesonide aerosol inhalation in the treatment of PAB can promote the disappearance of clinical symptoms,control inflammation,improve ventilation function,and have high safety.
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