摘要
目的:探究程序性细胞死亡受体蛋白-1/程序性细胞死亡配体蛋白-1(Programmed death 1/programmed death ligand 1,PD-1/PD-L-1)联合微卫星稳定性检测在子宫内膜癌诊断中的应用价值.方法:将 2021 年1 月至 2024 年1 月我院收治的 66 例疑似子宫内膜癌患者纳入研究.所有患者均接受刮宫病理诊断和微卫星稳定性检测及 PD-1/PD-L1 检测,使用Kappa检验分析微卫星稳定性检测、PD-1/PD-L1 检测和联合检测与刮宫病理诊断结果的一致性,并分析诊断效能.结果:经刮宫病理诊断,66 例疑似子宫内膜癌患者中共确诊 51 例,15 例为良性病变.微卫星稳定性检测结果与病理结果的Kappa值为 0.557,一致性一般;PD-1/PD-L1 检测结果与病理结果的Kappa值为 0.575,一致性一般;联合检测结果与病理结果的Kappa值为 0.670,一致性较高.微卫星稳定性检测的敏感度、特异度和准确率分别为 86.27%、73.33%、83.33%;PD-1/PD-L1 检测的敏感度、特异度和准确率分别为 84.31%、80.00%、83.33%;联合检测的敏感度、特异度和准确率分别为 90.20%、80.00%、87.88%.结论:微卫星稳定性检测和 PD-1/PD-L1 检测在子宫内膜癌的临床诊断中的应用效果较好,二者联合可有效提高临床诊断率,具有较高的诊断价值.
Abstract
Objective:To explore the detection value of microsatellite stability and programmed death 1/programmed death ligand 1(PD-1/PD-L1)expression in patients with endometrial cancer.Method:66 suspected endometrial cancer patients admitted to our hospital from January 2021 to January 2024 were included in the study.All patients underwent curettage pathology diagnosis,microsatellite stability testing,and PD-1/PD-L1 testing.Kappa test was used to analyze the consistency between microsatellite stability testing,PD-1/PD-L1 testing,and combined testing with curettage pathology diagnosis results,and diagnostic efficacy was analyzed.Result:The pathological diagnosis by curettage and curettage showed that 51 suspected endometrial cancer patients were diagnosed,and 15 cases were benign lesions.The Kappa value between the stability test results of microsatellites and the pathological results is 0.557,indicating moderate consistency;The Kappa value between the PD-1/PD-L1 detection results and the pathological results is 0.575,indicating moderate consistency;The Kappa value between the joint detection results and the pathological results is 0.670,indicating high consistency.The sensitivity,specificity,and accuracy of microsatellite stability detection are 86.27%,73.33%,and 83.33%,respectively;The sensitivity,specificity,and accuracy of PD-1/PD-L1 detection were 84.31%,80.00%,and 83.33%,respectively;The sensitivity,specificity,and accuracy of the combined detection were 90.20%,80.00%,and 87.88%,respectively.Conclusion:The application of microsatellite stability testing and PD-1/PD-L1 detection in the clinical diagnosis of endometrial cancer is effective.The combination of the two can effectively improve the clinical diagnosis rate and has high diagnostic value.
维普
万方数据