Relationship between the expression of serum albumin and cholinesterase and the prognosis of AECOPD patients with respiratory failure
Objective:To explore the exacerbation of chronic obstructive pulmonary disease in serum Albumin(ALB)and Cholinesterase(CHE)respectively.The expression of AECOPD in patients with respiratory failure combined with ventilation therapy was analyzed,and the relationship between them and the prognosis of patients with ventilation therapy was analyzed.Methods:From January 2021 to December 2023,90 AECOPD patients with respiratory failure who were diagnosed and planned to undergo ventilation treatment in our hospital were selected as the research objects.All patients were followed up for 1 year after ventilation treatment.The patients who died during the follow-up period were included in the poor prognosis group(19 cases),and the other patients were included in the good prognosis group(71 cases).The serum ALB and CHE levels of all patients at admission(before treatment)and after treatment,and the serum ALB and CHE levels of AECOPD patients with different prognosis at admission were detected and compared.The restrictive cubic spline model and Logistic regression were used to analyze the relationship between serum ALB and CHE at admission and the poor prognosis of patients with ventilation treatment.Results:On the 7 th day of treatment,the levels of serum ALB and CHE in AECOPD patients with respiratory failure were significantly higher than those before treatment(P<0.05).The levels of serum ALB and CHE in the poor prognosis group were significantly lower than those in the good prognosis group(P<0.05).According to the analysis of restricted cubic spline model,the correlation between serum ALB and CHE levels at admission and the risk of poor prognosis in AECOPD patients with respiratory failure was nonlinear dose-response relationship(P<0.05).Logistic regression analysis showed that serum ALB and CHE were protective factors for poor prognosis in AECOPD patients with respiratory failure after ventilation treatment(OR<1,P<0.05).Conclusions:There was a non-linear dose-response relationship between serum ALB and CHE levels and the risk of poor prognosis after ventilation treatment,and serum ALB and CHE were protective factors for the prognosis of ventilation treatment.
万方数据
维普
