首页|抗HPV敷料联合保妇康栓、rhIFNα-2b凝胶治疗高危HPV感染患者的临床疗效

抗HPV敷料联合保妇康栓、rhIFNα-2b凝胶治疗高危HPV感染患者的临床疗效

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目的:探讨抗人乳头瘤病毒(Human papillomavirus,HPV)生物蛋白敷料(简称:抗HPV敷料)联合保妇康栓、重组人干扰素α-2b(Recombinant human interferonα-2b,rhIFNα-2b)凝胶治疗高危HPV感染患者的临床疗效.方法:选取 2021 年 1 月~2022 年 12 月中牟县人民医院收治的 125 例高危HPV感染患者作为研究对象,根据治疗方法不同分为常规组(n=62)和敷料联合组(n=63),常规组采用保妇康栓、rhIFNα-2b凝胶治疗,敷料联合组在常规组基础上联合抗HPV敷料治疗.治疗 3 个疗程后(治疗后),比较两组临床疗效、HPV转阴率、不良反应及治疗前后临床症状积分、阴道微环境因子[(白细胞酯酶(Leukocyte esterase,LE)、过氧化氢(Hydrogen peroxide,H2O2)、唾液酸苷酶(Sialy glycoside enzyme,SNA)]阳性率、血清炎性因子[白细胞介素(Interleukin,IL)-1、IL-6、IL-10、IL-17]、免疫功能[免疫球蛋白(Immunoglobulin,Ig)A、IgG、IgM、表面抗原分化簇(Cluster of differentiation,CD)4+、CD8+].治疗后随访 6 m,比较两组HPV复发情况.结果:敷料联合组总有效率、HPV转阴率高于常规组(P<0.05);而两组不良反应发生率比较,无显著差异(P>0.05);治疗后,敷料联合组临床症状积分、阴道微环境因子阳性率、血清IL-1、IL-6、IL-17 水平及CD8+低于常规组,血清IL-10、IgA、IgG、IgM水平及CD4+高于常规组(P<0.05);治疗后随访 6 m,敷料联合组HPV复发率低于常规组(P<0.05).结论:抗HPV敷料联合保妇康栓、rhIFNα-2b2 b治疗高危HPV感染患者具有较好的临床疗效,可促进HPV转阴,改善临床症状和阴道微环境,纠正炎性-免疫因子失衡状态,并可降低HPV复发率,且具有较高的安全性.
Clinical efficacy of anti-HPV dressing combined with Baofukang suppository and rhIFN-α-2b gel in the treatment of high-risk HPV infection patients
Objective:To investigate the clinical efficacy of anti-human papillomaviru(HPV)bioprotein dressing(anti-HPV dressing)combined with Baofukang suppository and recombinant human interferonα-2b(rhIFN-α2b)gel in the treatment of high-risk HPV infection patients.Methods:A total of 125 patients with high-risk HPV infection admitted to Zhongmou County People's Hospital from January 2021 to December 2022 were selected and divided into conventional group(62 cases)and dressing-combined group(63 cases)according to different treatment methods.The conventional group was treated with Baofukang suppository and rhIFN-α2b gel,and the dressing-combined group was treated with anti-HPV dressings on the basis of the conventional group.After 3 courses of treatment(after treatment),the clinical efficacy,HPV negative conversion rate,adverse reactions,clinical symptom scores,positive rates of vaginal microenvironment factors[(leukocyte esterase,LE),hydrogen peroxide(H2O2),sialy glycoside enzyme(SNA)],serum inflammatory factors[interleukin(IL)-1,IL-6,IL-10,IL-17],immune function[immunoglobulin(Ig)A,IgG,IgM,cluster of differentiation(CD)4+,CD8+]before and after treatment were compared between the two groups.Followed up for 6 months after treatment,the recurrence of HPV was compared between the two groups.Results:The total effective rate and HPV negative conversion rate of dressing-combined group were higher than those of conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the clinical symptom score,positive rate of vaginal microenvironment factor,serum levels of IL-1,IL-6,IL-17 and CD8+in dressing-combined group were lower than those in conventional group,while serum levels of IL-10,IgA,IgG,IgM and CD4+were higher than those in conventional group(P<0.05).Followed up for 6 months after treatment,the recurrence rate of HPV in the dressing-combined group was lower than that in the conventional group(P<0.05).Conclusion:Anti-HPV dressing combined with Baofukang suppository and rhIFNα-2b has good clinical efficacy for high-risk HPV infection patients,which can promote HPV negative conversion,improve clinical symptoms and vaginal microenvironment,correct the imbalance of inflammatory and immune factors,and reduce the recurrence rate of HPV,with high safety.

Human papillomavirusAnti-HPV bioprotein dressingBaofukang suppositoryRecombinant human interferon α-2b

刘传会、王冰、王晓静、王志红

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Department of Obstetrics and Gynecology,Zhongmou People's Hospital,Zhongmou 451450,Henan,China

郑州大学第二附属医院妇科,河南 郑州 450000

人乳头瘤病毒 抗HPV生物蛋白敷料 保妇康栓 重组人干扰素α-2b

2024

四川生理科学杂志
四川省生理科学会

四川生理科学杂志

影响因子:0.575
ISSN:1671-3885
年,卷(期):2024.46(10)