Clinical efficacy of anti-HPV dressing combined with Baofukang suppository and rhIFN-α-2b gel in the treatment of high-risk HPV infection patients
Objective:To investigate the clinical efficacy of anti-human papillomaviru(HPV)bioprotein dressing(anti-HPV dressing)combined with Baofukang suppository and recombinant human interferonα-2b(rhIFN-α2b)gel in the treatment of high-risk HPV infection patients.Methods:A total of 125 patients with high-risk HPV infection admitted to Zhongmou County People's Hospital from January 2021 to December 2022 were selected and divided into conventional group(62 cases)and dressing-combined group(63 cases)according to different treatment methods.The conventional group was treated with Baofukang suppository and rhIFN-α2b gel,and the dressing-combined group was treated with anti-HPV dressings on the basis of the conventional group.After 3 courses of treatment(after treatment),the clinical efficacy,HPV negative conversion rate,adverse reactions,clinical symptom scores,positive rates of vaginal microenvironment factors[(leukocyte esterase,LE),hydrogen peroxide(H2O2),sialy glycoside enzyme(SNA)],serum inflammatory factors[interleukin(IL)-1,IL-6,IL-10,IL-17],immune function[immunoglobulin(Ig)A,IgG,IgM,cluster of differentiation(CD)4+,CD8+]before and after treatment were compared between the two groups.Followed up for 6 months after treatment,the recurrence of HPV was compared between the two groups.Results:The total effective rate and HPV negative conversion rate of dressing-combined group were higher than those of conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the clinical symptom score,positive rate of vaginal microenvironment factor,serum levels of IL-1,IL-6,IL-17 and CD8+in dressing-combined group were lower than those in conventional group,while serum levels of IL-10,IgA,IgG,IgM and CD4+were higher than those in conventional group(P<0.05).Followed up for 6 months after treatment,the recurrence rate of HPV in the dressing-combined group was lower than that in the conventional group(P<0.05).Conclusion:Anti-HPV dressing combined with Baofukang suppository and rhIFNα-2b has good clinical efficacy for high-risk HPV infection patients,which can promote HPV negative conversion,improve clinical symptoms and vaginal microenvironment,correct the imbalance of inflammatory and immune factors,and reduce the recurrence rate of HPV,with high safety.
Human papillomavirusAnti-HPV bioprotein dressingBaofukang suppositoryRecombinant human interferon α-2b
刘传会、王冰、王晓静、王志红
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Department of Obstetrics and Gynecology,Zhongmou People's Hospital,Zhongmou 451450,Henan,China