Correlation between transvaginal three-dimensional ultrasound parameters,serum VEGF and TIMP-1 levels,and the degree of intrauterine adhesions
Objective:To investigate the correlation between transvaginal three-dimensional ultrasound(3D-TVS)parameters,serum vascular endothelial cell growth factor(VEGF),matrix metalloproteinase inhibitor-1(TIMP-1),and the degree of intrauterine adhesions.Methods:A total of 76 patients with intrauterine adhesions who were treated in our hospital from June 2022 to June 2023 were selected as the adhesion group,and another 76 patients with normal endometrium were selected as the control group.The parameters of 3D-TVS and serum VEGF and TIMP-1 levels were compared between the two groups and among patients with different degrees of adhesions,and the correlation and diagnostic value were analyzed.Results:There were significant differences in the 3D-TVS parameters and serum VEGF and TIMP-1 levels between the two groups(P<0.05).The serum VEGF and TIMP-1 levels increased with the severity of intrauterine adhesions,while the 3D-TVS parameters decreased with the severity of intrauterine adhesions(P<0.05).The severity of intrauterine adhesions was negatively correlated with the 3D-TVS parameters,and positively correlated with the serum VEGF and TIMP-1 levels(P<0.05);the AUCs of the combined diagnosis of moderate and severe intrauterine adhesions using 3D-TVS parameters,serum VEGF,and TIMP-1 levels were 0.920 and 0.947,respectively.Conclusion:The parameters of 3D-TVS combined with serum levels of VEGF and TIMP-1 are closely related to the degree of intrauterine adhesions and have high diagnostic value.
万方数据
维普
