Detection value of serum ChE,PA and HBsAg in patients with chronic hepatitis B and different degree of inflammatory response
Objective:To explore clinical detection value of serum cholinesterase(ChE),prealbumin(PA)and hepatitis B surface antigen(HBsAg)in patients with chronic hepatitis B(CHB)and different degree of inflammatory response.Methods:A retrospective analysis was performed on the clinical data of 130 patients with CHB in the hospital between July 2021 and July 2023.According to presence or absence of inflammatory response,patients were divided into G≥2 group(n=86)and G<2 group(n=44).According to different degree of inflammatory response,patients were divided into mild group(n=44),moderate group(n=40)and severe group(n=46).The levels of ChE,PA and HBsAg in different groups were compared,and their detection value for G≥2 inflammatory response was analyzed by area under receiver operating characteristic(ROC)curve(AUC).Results:The levels of ChE,PA and HBsAg in G≥2 group were lower than those in G<2 group(P<0.05).The levels of ChE,PA and HBsAg in mild group were higher than those in moderate group and severe group,and levels of ChE and HBsAg in moderate group were higher than those in severe group(P<0.05).The levels of ChE,PA and HBsAg were negatively correlated with inflammatory response degree.The results of ROC curves analysis showed that AUC and sensitivity of serum ChE combined with PA and HBsAg for detecting G≥2 inflammatory response were 0.883 and 82.56%,higher than those of single index(0.789,0.743,0.658;74.42%,70.93%,66.28%).Conclusion:Serum ChE,PA,HBsAg and combined detection all have detection value in patients with chronic hepatitis B and different degree of inflammatory response,which is worthy of clinical reference.
Chronic hepatitis BCholinesterasePrealbuminHepatitis B surface antigen
万方数据
维普
