Analgesic effect of sufentanil and fentanyl for PCIA and their influences on stress response and hemodynamics after cesarean section
Objective:To explore the analgesic efficacy,stress response,and hemodynamic effects of sufentanil and fentanyl in patient-controlled intravenous analgesia(PCIA)after cesarean section.Methods:Retrospective analysis of the data of 96 patients who underwent cesarean section in our hospital from June 2022 to June 2024.According to the different medication regimens in the postoperative PCIA,they were divided into group A(n=42,using fentanyl citrate injection)and group B(n=54,using sufentanil citrate injection).The analgesic and sedative effects were evaluated using the Visual analogue pain score(VAS)and Ramsay sedation scale at 6,12,and 24 hours after surgery.High-sensitivity C-reactive protein(hs-CRP)and endothelin-1(ET-1)were detected by enzyme-linked immunosorbent assay before and 2 hours after surgery,and noradrenaline(NE)was detected by high performance liquid chromatography.Plasma cortisol(COGT)was detected by radioimmunoassay.The mean arterial pressure(MAP),heart rate(HR),and oxygen saturation(SpO2)were recorded using an electrocardiogram monitor before and 2 hours after surgery,and evaluate the safety of drugs in the two groups of patients.Results:At 6,12,and 24 hours post-surgery,the VAS and Ramsay scores in Group B were significantly lower than those in Group A(P<0.05).Two hours after surgery,the levels of hs-CRP,COGT,NE,ET-1,HR,MAP,and SpO2 increased in both groups,but the levels of these indicators in group B were lower than those in group A(P<0.05).There was no significant difference in the overall adverse reaction rate between the two groups(11.11%vs 23.81%)(P>0.05).Conclusion:Compared with fentanyl,sufentanil has better analgesic effect in PCIA after cesarean section,which is beneficial to maintaining stable hemodynamics,and has less stress response on the parturient and is safe.
万方数据
维普
