Effects of different doses of aspirin on uterine arterial blood flow,levels of thrombolytic markers,and pregnancy outcomes in patients with pregnancy susceptibility
Effects of different doses of aspirin on uterine arterial blood flow,levels of thrombolytic markers,and pregnancy outcomes in patients with pregnancy susceptibility
Objective:To investigate the effects of different doses of aspirin on uterine artery blood flow,pregnancy outcome,and the level of markers of thrombolytic disorder in patients with pregnancy susceptibility.Methods:A total of 129 patients with pregnancy susceptibility were randomly divided into a control group and an observation group.The control group(n=64)was treated with 75 mg of aspirin orally,while the observation group(n=65)was treated with 50 mg.In both groups,the pulsatility index(PI),resistive index(RI),and peak systolic velocity/end-diastolic velocity(S/D)of the uterine artery was measured using a Doppler ultrasound diagnostic instrument.Plasma antithrombin III and D-dimer levels were measured using a Sysmex CN-6000 fully automated coagulation analyzer,and protein C and protein S activities were measured using a chromogenic substrate method.The pregnancy outcomes and adverse drug reactions were recorded.Results:There were no significant differences in PI,RI,S/D,protein C,plasma antithrombin III,protein S,and D-dimer between the two groups after treatment(P>0.05).The live birth rate in the observation group was higher than that in the control group,and the incidence of adverse reactions was lower than that in the control group(P<0.05).Conclusion:Compared with 75 mg aspirin,50 mg aspirin has the same effect on improving the uterine artery blood flow and the level of markers of thromboembolism during pregnancy.However,it has a better effect on improving pregnancy outcomes and high safety.
维普
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