Effects of different doses of aspirin on uterine arterial blood flow,levels of thrombolytic markers,and pregnancy outcomes in patients with pregnancy susceptibility
Objective:To investigate the effects of different doses of aspirin on uterine artery blood flow,pregnancy outcome,and the level of markers of thrombolytic disorder in patients with pregnancy susceptibility.Methods:A total of 129 patients with pregnancy susceptibility were randomly divided into a control group and an observation group.The control group(n=64)was treated with 75 mg of aspirin orally,while the observation group(n=65)was treated with 50 mg.In both groups,the pulsatility index(PI),resistive index(RI),and peak systolic velocity/end-diastolic velocity(S/D)of the uterine artery was measured using a Doppler ultrasound diagnostic instrument.Plasma antithrombin III and D-dimer levels were measured using a Sysmex CN-6000 fully automated coagulation analyzer,and protein C and protein S activities were measured using a chromogenic substrate method.The pregnancy outcomes and adverse drug reactions were recorded.Results:There were no significant differences in PI,RI,S/D,protein C,plasma antithrombin III,protein S,and D-dimer between the two groups after treatment(P>0.05).The live birth rate in the observation group was higher than that in the control group,and the incidence of adverse reactions was lower than that in the control group(P<0.05).Conclusion:Compared with 75 mg aspirin,50 mg aspirin has the same effect on improving the uterine artery blood flow and the level of markers of thromboembolism during pregnancy.However,it has a better effect on improving pregnancy outcomes and high safety.
万方数据
维普
