Changes of blood lactic acid and serum albumin in patients with acute respiratory failure during mechanical ventilation and their effects on the outcome of withdrawal
Objective:To analyze the changes of blood lactic acid and serum albumin in patients with acute respiratory failure during mechanical ventilation and their effects on the outcome of withdrawal.Methods:The clinical data of 106 patients with acute respiratory failure who received mechanical ventilation from June 2020 to May 2022 were retrospectively collected.Serum albumin and blood lactic acid levels were measured before withdrawal.According to the outcome of withdrawal,the patients were divided into failure group and successful group.Design a baseline data collection table to incorporate possible influencing factors.Logistic regression analysis was performed to find out the factors affecting the outcome of mechanical ventilation in patients with acute respiratory failure.Results:In 106 patients with acute respiratory failure,31 cases(29.25%)failed to withdraw the machine.The long-term smoking history ratio and blood lactic acid level in the failed group were significantly higher than those in the successful group,the mechanical ventilation time was significantly longer than that in the successful group,and the serum albumin level was significantly lower than that in the successful group(P<0.05).There were no significant differences in age,sex,body mass index,arterial blood oxygen partial pressure and arterial carbon dioxide partial pressure between the two groups(P>0.05).Logistic regression analysis showed that long-term smoking history,long mechanical ventilation time and high expression of blood lactic acid were the risk factors for the outcome of mechanical ventilation in patients with acute respiratory failure(OR>1,P<0.05),and high serum albumin expression was the protective factor(OR<1,P<0.05).Conclusion:High expression of blood lactic acid and low expression of serum albumin can increase the risk of withdrawal failure in patients with acute respiratory failure during mechanical ventilation,and long-term smoking history and mechanical ventilation time are related to the outcome of patients with acute respiratory failure.
万方数据
维普
