Pathogenic characteristics of sputum culture and drug resistance in patients with chronic obstructive pulmonary disease and ventilator-associated pneumonia
Pathogenic characteristics of sputum culture and drug resistance in patients with chronic obstructive pulmonary disease and ventilator-associated pneumonia
Objective:To analyze the pathogenic characteristics and drug resistance of sputum cultures in patients with chronic obstructive pulmonary disease complicated by ventilator-associated pneumonia.Methods:A total of 65 patients with chronic obstructive pulmonary disease complicated by ventilator-associated pneumonia were selected from January 2022 to March 2024.Sputum samples were cultured,and the composition and distribution of pathogenic bacteria in sputum culture were recorded.The drug resistance test was performed on major strains using the standard disk diffusion method(Kirby Bauer,K-B method),and the drug resistance status of each major strain was observed and recorded.Results:In 65 patients,the positive rate of sputum bacterial culture was 90.77%(59/65),among which single bacteria accounted for 35.38%(23/65),mixed infection with bacteria accounted for 55.38%(36/65)and mixed infection with fungus and bacteria accounted for 9.23%(6/65).A total of 131 strains were detected in the sputum culture,mainly including bacteria(123),among which Gram-negative bacilli accounted for 77.24%(95/123)and Gram-positive cocci accounted for 22.7%(28/123).Among the main gram-negative bacteria,Pseudomonas aeruginosa is most sensitive to polymyxin B;Acinetobacter baumannii is most sensitive to tigecycline;Escherichia coli and Klebsiella pneumoniae are sensitive to tigecycline and cefepime.Among the main gram-positive cocci,Staphylococcus aureus and coagulase-negative staphylococcus epidermidis were most sensitive to vancomycin.Candida tropicalis in fungi has poor sensitivity to fluconazole and itraconazole;Candida albicans exhibits good sensitivity to itraconazole;Candida parapsilosis is highly sensitive to itraconazole.Conclusion:Mixed infections are common in patients with this study,and the infection strains are mainly bacteria.The drug resistance of different pathogenic strains varies,so clinicians should choose drugs based on actual conditions.
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