Correlation between thyroid function indexes and oxidative stress indexes in patients with thyroid dysfunction
Objective:To analyze the correlation between thyroid function indexes and oxidative stress indexes in patients with thyroid dysfunction.Methods:A total of 50 patients with hyperthyroidism,50 patients with hypothyroidism and 50 healthy adults in the hospital were enrolled as hyperthyroidism group,hypothyroidism group and normal group between July 2023 and July 2024.The levels of thyroid function indexes[thyrotropin(TSH),free thyroid hormone(FT4),free triiodothyronine(FT3)]and oxidative stress indexes[malondialdehyde(MDA),superoxide dismutase(SOD),myeloperoxidase(MPO)]in the three groups were compared.The relationship between thyroid function indexes and oxidative stress indexes in hyperthyroidism group and hypothyroidism group was analyzed by Pearson correlation analysis.Results:TSH level in hyperthyroidism group was lower than that in normal group,while levels of FT4 and FT3 were higher than those in normal group.TSH level in hypothyroidism group was higher than that in normal group,while levels of FT4 and FT3 were lower than that in normal group(P<0.05).The levels of SOD and MPO in hyperthyroidism group and hypothyroidism group were lower than those in normal group,while MDA level was higher than that in normal group(P<0.05).The results of Pearson correlation analysis showed that in hyperthyroidism group,serum TSH was positively correlated with SOD and MPO,while negatively correlated with MDA(P<0.05).In hypothyroidism group,serum TSH was negatively correlated with SOD and MPO,while positively correlated with MDA(P<0.05).Conclusion:There is certain correlation between thyroid function indexes and oxidative stress indexes in patients with thyroid dysfunction.
万方数据
维普
