Clinical study of vitamin D2 in the treatment of diabetic peripheral neuropathy
Objective:To investigate the efficacy and safety of vitamin D2 in the treatment of diabetic peripheral neuropathy(DPN)by increasing the level of 25-hydroxyvitamin D[25(OH)D].Methods:92 T2DM patients with DPN treated in our hospital during 2022.2 to 2023.3 were selected as the study objects.The patients were randomly divided into control group and observation group,with 46 cases in each group.The control group was treated with mecobalamin tablets and lipoic acid injection.Observation group was given intramuscular injection of vitamin D2 on the basis of control group.Peripheral motor nerve conduction velocity(MCV),sensory nerve conduction velocity(SCV),levels of serum 25(OH)D,degree of neuropathy[Michigan Diabetic Neuropathy Scale(MDNS)score]and adverse reactions were analyzed and compared between the two groups.Results:After treatment,the levels of serum 25-OH VD2 and 25-OH VD3 in both groups were higher than those before treatment,and the levels of 25-OH VD2 and 25-OH VD3 in observation group were significantly higher than those in control group(P<0.05).After treatment,the levels of median nerve MCV,SCV and common peroneal nerve MCV and SCV in both groups were higher than those before treatment,and the levels of median nerve MCV,SCV and common peroneal nerve MCV and SCV in observation group were significantly higher than those in control group(P<0.05).After treatment,MDNS scores of both groups decreased compared with those before treatment,and MDNS scores of observation group were significantly lower than those of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion:Vitamin D2 injection can increase the level of serum 25(OH)D in T2DM patients with DPN,increase peripheral nerve conduction velocity,improve clinical symptoms and have high safety.
Vitamin D2 injectionDiabetic peripheral neuropathy25 hydroxyvitamin D
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