Dynamic monitoring of the changes in serum levels of TIM-4,GMP-140,and CRP during the treatment of severe pneumonia patients and their clinical significance
Objective:To investigate the changes and clinical significance of serum levels of T cell immunoglobulin mucin protein-4(TIM-4),granule membrane protein-140(GMP-140),and C-reactive protein(CRP)in patients with severe pneumonia during the treatment course.Methods:Seventy-nine patients with severe pneumonia admitted to our hospital from April 2021 to July 2023 were selected as the study group and seventy-nine patients with common pneumonia were selected as the control group,and the patient disease regression was evaluated.TIM-4,GMP-140,and CRP serum levels between two groups and patients with different outcomes were compared.The correlation and predictive value between the above indicators and disease outcomes were analyzed through partial regression analysis.Results:The levels of serum TIM-4,GMP-140,and CRP in the study group and patients with poor outcomes after 1,3,and 5 days of treatment were higher than those in the control group and patients with good outcomes,and it was found that with clinical treatment intervention,the levels of serum TIM-4,GMP-140,and CRP showed a downward trend(P<0.05).The detection of serum TIM-4,GMP-140,and CRP levels at 1 and 5 days of treatment had high value and risk in predicting poor outcomes.Conclusion:Dynamic monitoring of the changes in plasma levels of TIM-4,GMP-140,and CRP in patients with severe pneumonia is helpful for clinical disease monitoring and disease outcome assessment.
T cell immunoglobulin mucin protein-4Granule membrane protein-140C-Reactive ProteinSevere pneumonia
NETL
NSTL
万方数据
