Effect of two anticoagulant drugs on coagulation function in thromboprophylaxis of tumor patients
Objective:To study the effects of rivaroxaban and low molecular weight heparin(LMWH)on the coagulation function of tumor patients,as well as the safety and efficacy.Methods:A total of 60 patients with malignant tumors diagnosed and treated with chemotherapy were selected in our hospital from July 2019 to July 2022.Thirty patients treated with rivaroxaban were selected as the test group,and thirty patients treated with LMWH were selected as the control group.The coagulation indexes before and after medication,thrombosis and major bleeding events were compared between the two groups.Results:There were no significant differences in tumor location,underlying disease between the two groups;The D-dimer between the two groups after thrombus prophylaxis and before treatment were decreased significantly(P<0.05).No thrombus or major bleeding occurred in the two groups.Conclusion:Both rivaroxaban and LMWH have a clear effect on safety and efficacy in the prevention of thrombosis in tumor patients receiving chemotherapy,and both can significantly reduce patients'D-Dimer.Rivaroxaban might be used to prevent tumor-associated venous thromboembolism instead of LMWH.decreased D-dimer more significantly than LMWH.
RivaroxabanLow molecular weight heparinMalignant tumorVenous thrombosisCoagulation function
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