Effect analysis of endoscopic retrograde cholangiopancreatography combined with laparoscopy on patients with acute biliary pancreatitis
Objective:To study the effect of endoscopic retrograde cholangiopancreatography combined with laparoscopy in the treatment of patients with acute biliary pancreatitis.Methods:Retrospective analysis of clinical data of 103 patients with acute gallstone pancreatitis treated in our hospital from January 2020 to June 2023,and divided into observation group(n=53)and control group(n=50)according to different surgical methods.The former underwent laparoscopic cholecystectomy+endoscopic retrograde cholangiopancreatography for stone removal,while the latter underwent laparoscopic cholecystectomy+laparoscopic common bile duct exploration.The surgical indicators and complications of the two groups were compared,and serum levels of pepsinogen II(PG-II),D-lactate,pepsinogen I(PG-I),total bilirubin(TBIL),glutamyl transferase(GGT),aspartate aminotransferase(AST),amylase(AMS),advanced oxidation protein products(AOPPs),and superoxide dismutase(SOD)were detected by enzyme-linked immunosorbent assay at 3 days postoperatively.Results:The observation group had shorter hospitalization,food intake,and clinical symptom disappearance time than the control group,and had less bleeding volume and medical expenses than the control group(P<0.05).Compared with pre-operative levels,the levels of AOPPs,PG-II,and PG-I in each treatment group increased significantly,while the levels of D-lactate,TBIL,GGT,and AMS decreased significantly(P<0.05),with the observation group showing a more significant decrease(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:Laparoscopic cholecystectomy combined with endoscopic retrograde cholangiopancreatography for stone removal can promote the recovery of gastrointestinal and liver functions,improve biochemical indicators,accelerate the rehabilitation process,and have good safety.
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