Effects of mosapride combined with rabeprazole in patients with reflux esophagitis
Objective:To explore the effect of mosapride combined with rabeprazole in the treatment of reflux esophagitis.Methods:A total of 102 patients with reflux esophagitis who were treated in our hospital from November 2022 to November 2023 were randomly divided into a control group(n=49)and an observation group(n=53),and were treated with oral administration of Rabeprazole 10 mg,3 times·day-1 or oral administration of Mosapride 5 mg combined with Rabeprazole 10 mg,3 times·day-1.After 2 months of treatment,the clinical efficacy of the two groups was compared.At the same time,the levels of gastrin(GAS),pepsinogen 1(PG1),and pepsinogen 2(PG2)were detected using a fully automated biochemical analyzer.The levels of interleukin-1β(IL-1β),interleukin-2(IL-2),and interleukin-6(IL-6)were detected using enzyme-linked immunosorbent assay.The Polygram 98 kinetic parameters and monitoring system were used to detect the pressure of the lower esophageal sphincter,and the adverse reactions during the treatment period were statistically analyzed in both groups.Results:The clinical efficacy rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the levels of GAS and PG1 in both groups increased,while the level of PG2 decreased.The above indicators in the observation group were better than those in the control group(P<0.05).The levels of IL-1β,IL-2,and IL-6 in both groups after treatment were lower than those before treatment,and the above indicators in the observation group were better than those in the control group(P<0.05).The lower esophageal sphincter pressure in the observation group after treatment was higher than that in the control group(P<0.05),and the incidence of adverse reactions was significantly lower than that in the control group(P<0.05).Conclusion:Mosapride combined with Rabeprazole in the treatment of reflux esophagitis can improve the clinical efficacy,improve the levels of gastric hormones and inflammatory factors in patients,and reduce the occurrence of adverse reactions.
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