Value analysis of the expression levels and ratios of albumin and alkaline phosphatase in the diagnosis of non-alcoholic fatty liver disease
Objective:To explore the expression and clinical significance of albumin(ALB)and alkaline phosphatase(ALP)and their ratio(Albumin-to-alkaline phosphatase ratio,AAPR)in non-alcoholic fatty liver patients.Method:A total of 150 patients with fatty liver admitted to our hospital from January 2019 to May 2023 were selected as the observation group for the study.Patients were divided into non-alcoholic fatty liver group and alcoholic fatty liver group based on whether they were non-alcoholic,with 75 cases in each group.75 other patients with healthy liver function during the same period were selected as the control group for the study.The expression of ALB,ALP,and AAPR in three groups were analyzed and compared.According to the severity of non-alcoholic fatty liver,patients were divided into three levels:mild,moderate,and severe,and the expression and significance of AAPR in non-alcoholic fatty liver were analyzed.Result:The ALP levels in both groups of patients with fatty liver were significantly higher than those in the control group,while the ALB and AAPR levels were significantly lower than those in the control group(P<0.05).The ALP levels in patients with non-alcoholic fatty liver were significantly higher than those in the alcoholic fatty liver group,and the levels of ALB and AAPR were significantly lower than those in the alcoholic fatty liver group(P<0.05).In this study,there were 75 patients with non-alcoholic fatty liver,of which 29 were mild(38.67%),31 were moderate(41.33%),and 15 were severe(20.00%).The levels of ALP in the severe and moderate groups of non-alcoholic fatty liver patients were significantly higher than those in the mild group(P<0.05),while the levels of ALB and AAPR were significantly lower than those in the mild group(P<0.05).The ALP levels in the severe group were significantly higher than those in the moderate group(P<0.05),while the ALB and AAPR levels were significantly lower than those in the moderate group(P<0.05).AAPR was negatively correlated with the severity of non-alcoholic fatty liver disease in patients(r<1,P<0.05).Conclusion:AAPR is abnormally reduced in non-alcoholic fatty liver patients,significantly lower than alcoholic fatty liver,and negatively correlated with the severity of the patient's condition.
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