Effect of compound ipratropium bromide combined with amoxicillin and clavulanate potassium in the treatment of children with lobar pneumonia
Objective:To analyze the efficacy of compound ipratropium bromide combined with amoxicillin clavulanate potassium in treating children with lobar pneumonia.Methods:Retrospectively collected clinical data of 108 children with lobar pneumonia admitted to our hospital from June 2021 to July 2023.The patients were divided into a control group and an observation group according to their different treatment plans,with 54 cases in each group.The control group was treated with amoxicillin and clavulanate potassium,300 mg·(kg·time)-1,intravenous infusion,once a day.The observation group was treated with amoxicillin,clavulanate potassium,and compound ipratropium bromide aerosol,2 sprays·time-1,twice a day.After 14 days of treatment,respiratory work(WOB),airway resistance(Raw),and peak airway pressure(PIP)were measured using a respiratory function detector.Interleukin 17(IL-17),interleukin 33(IL-33),and high mobility group box-1 protein(HMGB1)were measured using enzyme-linked immunosorbent assay.The clinical efficacy,symptom improvement time(cough relief time,fever subsidence time,lung rale disappearance time),and adverse reactions were analyzed.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The time for cough suppression,fever reduction,and disappearance of lung rales in the observation group was significantly shorter than in the control group(P<0.05).After treatment,the WOB,Raw,PIP,IL-17,IL-33,and HMGB1 levels in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compound ipratropium bromide combined with amoxicillin and clavulanate potassium in the treatment of lobar pneumonia can inhibit inflammation,improve respiratory mechanics,promote clinical symptoms,and improve clinical efficacy,with high safety.
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