Changes of serum PCT,D-D and WBC levels in patients with sepsis and their clinical value were dynamically monitored
Objective:To investigate the changes and clinical value of serum procalcitonin(PCT),D-dimer(D-D)and white blood cell count(WBC)in patients with sepsis during course of treatment.Methods:71 patients with sepsis admitted to our hospital from December 2021 to December 2023 were selected as the study objects.According to the outcome of the patients 1 month after treatment,the patients were divided into a good outcome group(52 cases)and a poor outcome group(19 cases).The serum PCT,D-D and WBC levels on the 1st,3rd and 7th day after admission were compared between the two groups,and the correlation between the serum PCT,D-D and WBC levels and the outcome was analyzed,as well as the predictive value of the three levels on the 7th day after admission to the patients with poor outcome was analyzed.Results:The serum PCT,D-D and WBC levels of the good outcome group were significantly lower than those of the poor outcome group at 1,3 and 7 days after admission(P<0.05).Serum PCT,D-D and WBC at 3 and 7 days after admission were the risk factors for poor outcome(P<0.05).The levels of serum PCT,D-D and WBC and the area under the curve(AUC)of the patients with combined prediction of adverse outcomes were 0.622,0.694,0.687 and 0.885,respectively,and the Yoden index was 0.324,0.415,0.410 and 0.597(P<0.05).The risk of progression to adverse outcome was 6.881,2.495 and 4.459 times higher in patients with high level of serum PCT,D-D and WBC on the 7th day after admission than in patients with low level(P<0.05).Conclusion:Serum PCT,D-D and WBC levels change significantly during the course of treatment in patients with sepsis.Dynamic monitoring can provide an effective reference for clinical prediction of outcomes.
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