Predictive value of serum AFP and Ferr for the efficacy of hepatic transcatheter arterial chemoembolization in patients with liver cancer
Objective:To analyze the relationship between serum alpha-fetoprotein(AFP)and ferritin(Ferr)and the curative effect of hepatic transcatheter arterial chemoembolization(TACE)in patients with liver cancer,and to evaluate its predictive value for the curative effect.Methods:86 patients with liver cancer who received TACE treatment in our hospital from January 2021 to April 2023 were selected as the study objects.Serum AFP and Ferr levels were detected before operation.The therapeutic effect 6 months after the operation was analyzed,and the patients were divided into ineffective group and effective group according to the therapeutic effect.The relationship between serum AFP,Ferr and TACE efficacy in patients with liver cancer were analyzed.The receiver operating characteristic(ROC)curve was plotted to evaluate its predictive value.Results:After 6 months of TACE treatment.There were 40 ineffective cases and 46 effective cases.The serum AFP and Ferr in the ineffective group were significantly higher than those in the effective group(P<0.05).Point two-column correlation analysis showed that serum AFP and Ferr were positively correlated with TACE efficacy in patients with liver cancer(r>0,P<0.05).The AUC of serum AFP and Ferr independently predicted the TACE efficacy of liver cancer patients was>0.7,and the AUC of combined prediction was>0.8.Conclusion:Serum AFP and Ferr are closely related to the efficacy of TACE in patients with liver cancer,and the higher level of serum AFP and Ferr before surgery,the greater possibility of ineffective TACE treatment in patients with liver cancer.
Liver cancerHepatic arterial chemoembolizationAlpha-fetoproteinFerritinPredictive value
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