血清FGFR4、HSP90α、OPN联合检测对晚期宫颈癌患者新辅助化疗近期疗效的评估价值
Evaluation value of serum FGFR4,HSP90α and OPN for short-term curative effect of neoadjuvant chemotherapy in patients with advanced cervical cancer
吴琼1
作者信息
- 1. 广丰区人民医院检验科,江西 上饶 334600
- 折叠
摘要
目的:探讨血清成纤维细胞生长因子受体 4(Recombinant Fibroblast Growth Factor Receptor 4,FGFR4)、中热休克蛋白 90α(Heat Shock Protein 90 α,HSP90α)、骨桥蛋白(Osteopontin,OPN)联合检测对晚期宫颈癌患者新辅助化疗近期疗效的评估价值.方法:选取 2023 年 1 月至 2024 年 5 月在我院就诊的 60 例晚期宫颈癌患者的临床资料进行研究.所有患者均顺利完成 3 个周期紫杉醇+卡铂新辅助化疗,化疗前留取血清样本.按照患者近期疗效,将其分为有效组与无效组.比较两组患者化疗前的FGFR4、HSP90α、OPN水平,使用受试者工作特征(Receiver Operating Characteristic,ROC)曲线分析FGFR4、HSP90α、OPN对新辅助化疗近期疗效的预测价值.结果:60 例晚期宫颈癌患者中治疗有效 39 例,占比65.00%.有效组患者血清FGFR4、HSP90α、OPN均小于无效组(P＜0.05).ROC曲线分析结果显示FGFR4、HSP90α、OPN及其联合预测新辅助化疗近期疗效的曲线下面积(AUC)分别为 0.793、0.713、0.803、0.923,均具有一定预测价值(P＜0.05).结论:FGFR4、HSP90α、OPN单独检测对晚期宫颈癌患者新辅助化疗近期疗效有一定预测价值,联合检测预测效能更高.
Abstract
Objective:To explore the evaluation value of serum recombinant fibroblast growth factor receptor 4(FGFR4)combined with heat shock protein 90α(HSP90α)and osteopontin(OPN)for short-term curative effect of neoadjuvant chemotherapy in patients with advanced cervical cancer.Methods:The clinical data of 60 patients with advanced cervical cancer in the hospital between January 2023 and May 2024 were collected.All patients successfully underwent paclitaxel+carboplatin neoadjuvant chemotherapy for 3 cycles,and serum samples were collected before chemotherapy.According to short-term curative effect,patients were divided into effective group and ineffective group.The levels of FGFR4,HSP90α and OPN were compared between the two groups,and their predictive value for short-term curative effect of neoadjuvant chemotherapy was analyzed by receiver operating characteristic(ROC)curves.Results:Among 60 patients with advanced cervical cancer,there were 39 cases(65.00%)with effective treatment.The levels of serum FGFR4,HSP90α and OPN in effective group were lower than those in ineffective group(P<0.05).The results of ROC curves analysis showed that area under the curve(AUC)values of FGFR4,HSP90α,OPN and combined detection for predicting short-term curative effect of neoadjuvant chemotherapy were 0.793,0.713,0.803 and 0.923,all showing certain predictive value(P<0.05).Conclusion:FGFR4,HSP90α and OPN all have certain predictive value for short-term curative effect of neoadjuvant chemotherapy in patients with advanced cervical cancer,and combined detection has higher predictive efficiency.
关键词
成纤维细胞生长因子受体4/中热休克蛋白90α/骨桥蛋白/晚期宫颈癌/新辅助化疗近期疗效Key words
Fibroblast growth factor receptor 4/Heat shock protein 90α/Osteopontin/Advanced cervical cancer/Short-term curative effect of neoadjuvant chemotherapy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据