目的:急性脑梗死(Acute Cerebral Infarction,ACI)患者应用纳洛酮联合阿司匹林治疗的临床效果.方法:将 68例ACI患者,通过抛掷骰子法随机分为对照组和联合组各 34 例,其中对照组给予阿司匹林口服治疗,初始剂量为 100 mg·d-1,而后改为200 mg·d-1,联合组在其基础上加用纳洛酮 0.4 mg静脉滴注治疗,其余常规治疗措施两组保持一致,两组均治疗 5 d.对比两组治疗 5 d后的临床疗效,分析治疗前后两组神经功能[美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)]、认知功能[简易智力状态检查表(Mini-Mental State Examination,MMSE)]变化,并采用全自动血液分析仪检测凝血功能指标[血小板计数(Platelet count,PLT)、D-二聚体(D-dimer,D-D)、纤维蛋白原(Fibrinogen,FIB)]水平.结果:治疗 5 d后,联合组治疗总有效率显著高于对照组(P＜0.05);两组患者NIHSS评分、PLT、D-D、FIB水平均下降,且联合组更低(P＜0.05);两组患者MMSE评分显著上升,且联合组更高(P＜0.05).结论:纳洛酮联合阿司匹林治疗ACI患者疗效显著,可改善其凝血功能,有利于神经功能及认知功能修复.
Clinical effect of naloxone combined with aspirin on patients with acute cerebral infarction
Objective:To analyze the clinical effect of naloxone combined with aspirin in the treatment of patients with acute cerebral infarction(ACI).Methods:Totally 68 patients with ACI were randomly divided into control group and combined group by means of throwing dice method,34 cases in each group.The control group was given aspirin orally(initial dose of 100 mg/day and then changed to 200 mg/day),while the combined group was combined with intravenous drip of 0.4 mg of naloxone on the basis of the control group.The other conventional treatment measures were consistent between the two groups.Both groups were treated for 5 days.The clinical efficacy was compared after 5 days of treatment,and the neurological function[National Institutes of Health Stroke Scale(NIHSS)]and cognitive function[Mini-Mental State Examination(MMSE)]were analyzed in both groups before and after treatment.The coagulation function indicators[platelet count(PLT),D-dimer(D-D),fibrinogen(FIB)]were detected by fully automatic hematology analyzer.Results:The total effective rate of treatment in combined group after 5 days of treatment was significantly higher than that in control group(P<0.05).The NIHSS score and levels of PLT,D-D and FIB in the two groups were decreased,and the score and levels in combined group were lower(P<0.05).The MMSE score was increased significantly in both groups,and the score was higher in combined group(P<0.05).Conclusion:Naloxone combined with aspirin has significant efficacy in the treatment of ACI patients,and it can improve the coagulation function,and it is conducive to the repair of neurological function and cognitive function.
NaloxoneAspirinAcute cerebral infarctionNeurological functionCognitive functionCoagulation function
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