Clinical application of different doses of nalbuphine combined with propofol in painless three-dimensional after loading radiotherapy for cervical malignant tumors
Objective:To observe the clinical application of different doses of nalbuphine combined with propofol in painless three-dimensional after loading radiotherapy for cervical malignant tumors.Methods:Sixty patients who underwent painless three-dimensional after loading radiotherapy for cervical malignant tumors at Jiangxi Maternal and Child Health Hospital from December 2023 to May 2024 were selected as the study subjects.According to the random number table method,they were divided into group A(30 cases)and group B(30 cases),receiving anesthesia with low-dose(0.1mg/kg)nalbuphine combined with propofol and anesthesia with high-dose(0.2mg/kg)nalbuphine combined with propofol,respectively.Mean arterial pressure(MAP),heart rate(HR)and blood oxygen saturation(SPO2)before anesthesia induction(T0),at the beginning of surgery(T1),at 10 min after the beginning of surgery(T2)and at the end of surgery(T3)were compared between the groups.Wake-up time and time for off-bed activities were recorded.The Visual Analog Scale(VAS)was used to evaluate pain degree at 1 hour and 2 hours after surgery.Adverse reactions were observed.Results:At T1,T2 and T3,group B had higher MAP and lower SPO2 than group A(P<0.05).Postoperative wake-up time and time for off-bed activities of group B were longer than those of group A(P<0.05).The two groups had comparable VAS scores at 1 hour and 2 hours after surgery(P>0.05).The incidence of adverse reactions in group B was higher than that in group A(P<0.05).Conclusion:0.1mg/kg and 0.2mg/kg of nalbuphine separately combined with propofol both can achieve good analgesic effects in painless three-dimensional after loading radiotherapy for cervical malignant tumors.However,postoperative recovery time of patients receiving the former anesthesia method is shorter,and it is safer.
NalbuphinePropofolCervical malignant tumorThree-dimensional after loading radiotherapy
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