Clinical study of doxycycline combined with methylprednisolone in treatment of refractory mycoplasma pneumonia in children
Objective:To analyze the effect of doxycycline combined with methylprednisolone in the treatment of children with refractory Mycoplasma pneumoniae pneumonia(RMPP).Methods:Ninety children with RMPP admitted to the first ward of the Department of Pediatrics in our hospital from January 2022 to December 2023 were selected as the study objects.The children were randomly divided into control group and observation group,45 cases in each group.The control group was treated with doxycycline on the basis of general treatment;Observation group was treated with methylprednisolone on the basis of control group.The immune function,the level of inflammatory factors,the time for the main symptoms to disappear and the occurrence of adverse reactions were analyzed and compared between the two groups.Results:After 14 days of treatment,the levels of immunoglobulin A(IgA),IgM,IgG,white blood cell count(WBC),C-reactive protein(CRP)and interleukin-6(IL-6)in observation group were significantly lower than those in control group(P<0.05).The disappearance time of fever,cough and pulmonary rales in observation group was significantly shorter than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Doxycycline combined with methylprednisolone in the treatment of RMPP in children can improve the immune function,relieve inflammation,promote the alleviation of main symptoms,and do not increase the adverse reaction of medication,with high safety.
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