Effect of load-dose atorvastatin on cardiovascular events and infection-related complications in elderly patients with acute myocardial infarction after PCI
Objective:To investigate the effect of preoperative atorvastatin loading dose on cardiovascular events and infection-related complications in elderly patients with acute myocardial infarction(AMI)undergoing percutaneous coronary intervention(PCI).Method:Eighty elderly patients with AMI who underwent PCI in our hospital from October 2021 to October 2023 were selected and treated with atorvastatin.They were divided into a control group(regular dose of 20 mg)and a study group(loading dose of 40-80 mg)according to different doses,with 40 cases in each group.After 3 months of treatment,the incidence of cardiovascular events in patients was statistically analyzed.The levels of left ventricular cardiac output(CO),left ventricular ejection fraction(LVEF),and left ventricular end-diastolic diameter(LVEDD)were measured using a Philips EPIQ CVx Doppler echocardiogram before and after PCI.The levels of serum creatine kinase isoenzymes MB(CK-MB)and cardiac troponin I(cTnI)were measured using immunosuppression and chemiluminescence methods,and the incidence of complications in patients was statistically analyzed.Results:The total incidence of cardiovascular events,LVEDD,and myocardial injury markers after PCI in the study group were significantly lower than those in the control group,while CO and LVEF were considerably higher than those in the control group(P<0.05).Conclusion:The use of atorvastatin in the elderly with AMI can reduce myocardial injury during PCI,lower the incidence of cardiovascular events,and improve cardiac function.
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