亚低温联合胞磷胆碱对急诊重度一氧化碳中毒患者预后的影响
Effect of mild hypothermia combined with citicoline on prognosis of emergency patients with severe carbon monoxide poisoning
豆路沙1
作者信息
- 1. 河南省直第三人民医院急诊科,河南 郑州 450000
- 折叠
摘要
目的:探讨亚低温联合胞磷胆碱对急诊重度一氧化碳(Carbon monoxide,CO)中毒患者预后的影响.方法:选取 2020年 1 月至 2023 年6月期间本院急诊科诊治的 80 例重度CO中毒患者作为研究对象,随机分为对照组和观察组,各 40 例.对照组患者肌肉注射胞磷胆碱注射液治疗,观察组在对照组的基础上联合亚低温治疗.分析比较两组的临床疗效、炎症因子水平[白细胞介素 6(Interleukin-6,IL-6)、C-反应蛋白(C-reactive protein,CRP)、全身免疫炎症指数(Systemic Immune Inflammation Index,SII)]、并发症及清醒率.结果:观察组的治疗总有效率明显高于对照组(P＜0.05).治疗前,两组的IL-6、CRP水平和SII指数均无明显差异(P＞0.05).治疗后,观察组的IL-6、CRP水平和SII指数均明显低于对照组(P＜0.05).观察组的并发症发生率明显低于对照组,清醒率明显高于对照组(P＜0.05).结论:亚低温联合胞磷胆碱能提升急诊重度 CO 中毒患者的临床疗效,降低炎症因子水平,减少患者并发症,提高清醒率.
Abstract
Objective:To investigate the effect of mild hypothermia combined with citicoline on prognosis of acute severe carbon monoxide(CO)poisoning patients.Methods:A total of 80 patients with severe CO poisoning diagnosed and treated in the emergency department of our hospital from January 2020 to June 2023 were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with intramuscular injection of citicoline injection,and the observation group was treated with mild low temperature on the basis of the control group.The clinical efficacy,inflammatory factor levels[interleukin-6(IL-6),C-reactive protein(CRP),systemic immunoinflammatory index(SII)],complications and wakefulness rate of the two groups were analyzed and compared.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Before treatment,there was no significant difference in IL-6,CRP levels,and SII index between the two groups(P>0.05).After treatment,the levels of IL-6,CRP,and SII index in the observation group were significantly lower than those in the control group(P<0.05).The incidence of complications in the observation group was significantly lower than that in the control group,and the wakefulness rate was significantly higher than that in the control group(P<0.05)Conclusion:Mild hypothermia combined with citicoline can improve the clinical efficacy of patients with severe CO poisoning in emergency,reduce the level of inflammatory factors,reduce the complications of patients,and increase the sobriety rate.
关键词
重度一氧化碳中毒/亚低温/胞磷胆碱Key words
Severe carbon monoxide poisoning/Mild low temperature/Citicoline引用本文复制引用
出版年
2024
NETL
NSTL
万方数据