Observation on the curative effect of balanceolium decoction combined with mesalazine enteric-coated tablets on the treatment of damp-heat ulcerative colitis
Objective:To observe the curative effect of Baitouweng decoction combined with mesalazine enteric-coated tab-lets on the treatment of damp-heat ulcerative colitis.Methods:Clinical data of 102patients with damp-heat ulcerative colitis ad-mitted to the hospital from March 2021to May 2022were retrospectively analyzed,and they were randomly divided into observation group(n=51,which was treated with Baitouweng decoction on the basis of control group)and control group(n=51,which was treated with mesalazine enteric-coated tablets)by the method of random number table.Both groups were treated for 4weeks.Tra-ditional Chinese medicine syndrome score,modified Mayo score system,Inflammatory Bowel disease Quality of Life Questionnaire(IBDQ),matrix metalloproteinase-1(MMP-1)and interleukin-1β(IL-β),diamine oxidase(DAO),D-lactic acid(D-LA),drug safety and clinical efficacy were compared between the two groups.Results:After treatment,the TCM syndrome score of both groups was decreased(P＜0.05),and the observation group was lower than control group(P＜0.05).The modified Mayo score after treatment was decreased in both groups(P＜0.05),and was lower in the observation group(P＜0.05).After treat-ment,IBDQ score was increased in both groups(P＜0.05),and higher in observation group(P＜0.05).After treatment,serum levels of MMP-1and IL-1βwere decreased in both groups(P＜0.05),and lower in observation group(P＜0.05).After treat-ment,serum DAO and D-LA levels were decreased in both groups(P＜0.05),and lower in observation group(P＜0.05).In the two groups,there was no difference in the incidence of total adverse reactions(P＞0.05).The observation group of total effective rate(94.12％)was higher than control group(80.39％)(P＜0.05).Conclusions:Pulsatilla decoction combined with mesalazine enteric-coated tablets is effective in the treatment of damp-heat ulcerative colitis,which can reduce the inflammatory response of patients,improve the quality of life and intestinal barrier function,and do not significantly increase the adverse drug reactions.
White head soupMesalazine enteric-coated tabletsDamp heat typeUlcerative colitisClinical effect
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