Observation of therapeutic effect and lymphocyte subsets about Bushenyangjing Decoction on Hypomenorrhea caused by DOR in stages
Objective:To observe the clinical effect of Bushenyangjing Decoction on Hypomenorrhea(kidney deficiency and blood stasis type)caused by Diminished Ovarian Reserve(DOR)in stages and the effect on peripheral blood lymphocyte sub-sets.Methods:70patients with Hypomenorrhea of kidney deficiency and blood stasis type caused by DOR were randomly divided into the treatment group(Bushenyangjing decoction)and the control group(Fenmotong).35patients in each group were treated in follicular phase and luteal phase for 3consecutive menstrual cycles.The clinical symptoms,serum hormone levels,lymphocyte subsets,antral follicle counting,changes in ovarian stromal blood flow and drug safety of the two groups were observed before and after treatment.Results:After treatment,for both groups of patients,on one hand,the scores of menstrual volume,bE2,CD4+T cells and B cells were increased,on the other hand,the scores of TCM syndrome serum bFSH,and CD8+T cells were de-creased(P＜0.05or P＜0.01).In the treatment group,menstrual score,ovarian interstitial PSV,AMH,and AFC were pro-longed,while RI were reduced(P＜0.05).Compared with the control group,the TCM syndrome score,CD8+T cells,and PI in the treatment group were significantly decreased(P＜0.05),while the menstrual volume score,menstrual period score,AMH,AFC,PSV,CD4+T cells,and B cells were clearly increased(P＜0.05).Compared between groups,the curative effect rate(48.57％)and total effective rate(88.57％)in the treatment group were apparently higher than the control group(28.57％,65.71％).No adverse events occurred during the study.Conclusion:Bushenyangjing Decoction can effectively improve the ovari-an reserve of patients with Hypomenorrhea(kidney deficiency and blood stasis type)caused by DOR,increase menstrual vol-ume,prolong menstrual period,improve ovarian interstitial blood flow,regulate the immune balance of the body,and has a bet-ter curative effect than hormone replacement therapy,which is worthy of clinical application.
Diminished Ovarian Reserve(DOR)HypomenorrheaKidney deficiency and blood stasisBushenyangjing DecoctionLymphocyte SubsetsOvarian Matrix
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