首页|中医药调控内质网应激治疗抑郁症的研究进展

中医药调控内质网应激治疗抑郁症的研究进展

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抑郁症是一类精神障碍的常见疾病,具有高患病率和复发率.内质网应激(ERS)通过激活未折叠蛋白反应(UPR)来介导包括抑郁症在内的多种精神疾病的发病机制.传统抗抑郁药物存在副反应大、药物依赖性强等不足,因此寻找疗效更佳的药物替代治疗必不可少,已成为时下治疗抑郁症方面的研究热点.研究发现中药及其有效成分、复方等中医疗法能发挥多途径、多环节、多靶点的作用机制,有效减少ERS诱导的神经细胞凋亡,从而发挥抗抑郁作用,改善抑郁症状.因此,运用中医药治疗由ERS介导的抑郁症值得总结与推广.
Research progress of traditional Chinese medicine in the treatment of depression in endoplasmic reticulum stress
Depression is a common disease of mental disorders with high prevalence and recurrence rate.Endoplasmic retic-ulum stress(ERS)mediates the pathogenesis of various mental diseases including depression by activating the unfolded protein response(UPR).Traditional antidepressants have the disadvantages of large side effects and strong drug dependence.Therefore,it is necessary to find better drug replacement therapy,which has become a research hotspot in the treatment of depression.Stud-ies have found that traditional Chinese medicine and its active ingredients,compound and other traditional Chinese medicine ther-apies can play a multi-channel,multi-link,multi-target mechanism of action,effectively reduce ERS-induced neuronal apopto-sis,thereby exerting antidepressant effects and improving depressive symptoms.Therefore,the use of traditional Chinese medicine in the treatment of depression mediated by ERS is worthy of summary and promotion.

traditional Chinese medicineendoplasmic reticulum stressdepressionreview

黄辰杰、樊明理、施学丽

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广西中医药大学研究生学院,广西南宁 530200

广西中医药大学壮医药学院,广西南宁 530001

中医药 内质网应激 抑郁症 综述

广西自然科学基金重点项目

2023GXNSFDA026048

2024

四川中医
四川省中医药学会,四川省中西医结合学会,四川省针灸学会,四川省中医药科学院

四川中医

CSTPCD
影响因子:0.522
ISSN:1000-3649
年,卷(期):2024.42(1)
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