Therapeutic effect of modified Buyang Huanwu Decoction combined with epalrestat on diabetic peripheral neuropa-thy of qi deficiency and blood stasis type and the influence on inflammatory factors,NRG 1and irisin
Objective:To analyze the therapeutic effect of modified Buyang Huanwu Decoction combined with epalrestat on diabetic peripheral neuropathy of qi deficiency and blood stasis type,and the influence on inflammatory factors,neuregulin 1(NRG1)and irisin.Methods:A total of 100patients with diabetic peripheral neuropathy of qi deficiency and blood stasis type who were diagnosed and treated in the hospital from May 2021to December 2022were selected,and randomly divided into the con-trol group(50patients treated with epalrestat)and the observation group(50patients treated with modified Buyang Huanwu De-coction combined with epalrestat).Results:After treatment,symptom scores and the levels of interleukin-6(IL-6),IL-8,C-reactive protein(CRP)and NRG 1 in the observation group were lower than those in the control group,and the level of irisin was higher than that in the control group(P＜0.05).The improvement of motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of median nerve and common peroneal nerve in the observation group was better than that in the con-trol group(P＜0.05).The total clinical effective rate in the observation group was higher than that in the control group(P＜0.05).Conclusion:Modified Buyang Huanwu Decoction combined with epalrestat is markedly effective in the treatment patients with diabetic peripheral neuropathy of qi deficiency and blood stasis type.The combined treatment can improve the symptoms of qi deficiency and blood stasis,NRG1and irisin levels and nerve conduction velocity,and lower the levels of inflammatory factors.
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