摘要
目的:利用数据挖掘技术分析糖尿病肾病(DN)的发病人群、核心症状、证素以及用药规律等.方法:在知网数据库中检索中医医案文献,纳入有效文献340篇,394例处方来构建数据库.通过Python、Gephi、SPSS等软件进行共现、关联等数据分析.结果:DN的发病人群主要为45～75岁的中老年男性;患者核心症状为乏力、口干、下肢水肿等;DN病位前期主要在肝、肾,后期主要在脾、肾;病性以气虚、血虚、阳虚、湿、阴虚最为常见;以黄芪-茯苓、黄芪-山药、黄芪-山茱萸等为最常使用的药对.结论:糖尿病肾病基本病机为肝、脾、肾为主的脏腑虚证为基础,夹杂着寒、热、湿、血瘀等;治疗上以益气养阴、补益肝肾为主.
Abstract
Objective:To analyze the incidence population,core symptoms,syndrome types,syndrome elements and medi-cation rules of diabetic nephropathy(DN)by using data mining technology.Methods:Chinese medical records were searched in the database of CNKI,and 340valid literatures and 394prescriptions were included to construct the database.The co-occurrence and correlation data were analyzed by Python,Gephi,SPSS and other software.Results:The incidence of DN was mainly 45～75years old men.The core symptoms of the patient were fatigue,dry mouth,lower limb edema,etc.The early stage of DN was mainly in liver and kidney,and the later stage was mainly in spleen and kidney.Qi deficiency,blood deficiency,Yang deficien-cy,dampness and Yin deficiency are the most common diseases.The most commonly used pairs are Astragalus-Poria,Astraga-lus-Yam,and Astragalus-Sanjus.Conclusion:The basic pathogenesis of diabetic nephropathy is based on zang fu deficiency syndrome of liver,spleen and kidney,mixed with cold,heat,dampness and blood stasis.The treatment mainly focuses on invig-orating qi and nourishing Yin and tonifying liver and kidney.
基金项目
新疆维吾尔自治区科技重大专项(2022A03019)
国家科技期刊平台
NSTL
万方数据