从"寒-痰-瘀"论逍遥蒌贝散对乳腺炎-癌转化的调控
Regulation of Xiaoyao Loubei Powder on Mammary Inflammatory-Cancer Transformation from"Cold-Phlegm-Stasis"Theory
龙柳伊 1王巧玲 1邓蒂斯2
作者信息
- 1. 成都中医药大学附属医院,四川成都 610072
- 2. 成都中医药大学附属医院,四川成都 610072;成都中医药大学,四川成都 610075
- 折叠
摘要
乳腺癌是高发恶性肿瘤,肥胖是其高危因素之一,炎-癌转化是恶性肿瘤发生和促进的重要机制.最新研究成果显示脂肪细胞深度参与了乳腺炎-癌转化过程,且该过程具有可控性,是防治乳腺癌的重要靶点机制.既往中医学多从"热-毒-瘀"角度探讨乳腺癌的治疗,但基于乳腺癌前期表现与古籍记载,阳虚阴盛也是早期乳腺癌发病的重要机制之一,且符合乳腺炎-癌转化的中医学病机.因此本文从"寒-痰-瘀"理论切入,探讨中医理论与肥胖相关乳腺炎-癌转化的机制契合处,并客观分析临床常用方逍遥蒌贝散的作用优势及在防止乳腺炎-癌转化的研究方向和作用潜力,以期为临床防治乳腺癌提供新的思路和研究方向.
Abstract
Breast cancer is a kind of high-risk malignant tumor,and obesity is one of its high-risk factors.Inflammation cancer transformation is an important mechanism for the occurrence and promotion of malignant tumors.Recently,scholars believe that adipocytes are deeply involved in the process of mammary inflammatory-cancer transformation,and the process is controlla-ble,which is an important target mechanism for the prevention and treatment of breast cancer.In the past,traditional Chinese medicine(TCM)mostly discussed the treatment of breast cancer from"hot-phlegm-stasis",but based on the early manifesta-tions of breast cancer and ancient records,Yang deficiency and Yin excess is also one of the important mechanisms of early breast cancer,which is the TCM pathogenesis of mammary inflammatory-cancer transformation.Therefore,this paper discusses the mechanism of TCM theory and obesity related inflammation cancer transformation from the perspective of'cold-phlegm-stasis'theory,Objective analysis of the clinical commonly used prescription Xiaoyao Loubei powder in the prevention of mammary inflam-matory-cancer transformation research direction and potential.In order to provide new ideas and research directions for clinical prevention and treatment of breast cancer.
关键词
乳腺癌/逍遥蒌贝散/乳腺炎-癌转化/肿瘤微环境/脂肪细胞/肥胖Key words
Breast cancer/Xiaoyao Loubei powder/inflammatory-cancer transformation/Tumor microenvironment/Adipo-cytes/Obesity引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据