Effect of Dachengqi decoction nasal feeding on oxygenation index,inflammatory factors,and intestinal mucosal barrier function in patients with severe pancreatitis complicated with lung injury
Objective:To explore the therapeutic effect of Dachengqi decoction combined with Western medicine on patients with severe acute pancreatitis(SAP)complicated with lung injury,and its impacts on oxygenation index,inflammatory factors,and intestinal mucosal barrier function.Methods:Ninety patients with SAP complicated with lung injury admitted to our hospital from October 2022to July 2023were collected as the study subjects and randomly grouped into two groups(45cases in the Chinese medicine group and 45cases in the conventional group).The conventional group was treated with Octreotide,while the Chinese medicine group was treated with Dachengqi decoction on the basis of the conventional group.The total effective rate,arterial blood gas indicators,clinical symptom relief time,hospital stay,levels of various inflammatory factors,T cell subpopulations,and in-testinal mucosal barrier function indicators were compared between the two groups after treatment.Results:After treatment,the total effective rate of 75.56％in the conventional group was obviously lower than that of 95.56％in the Chinese medicine group(P＜0.05);the arterial blood gas indicators in both groups were obviously increased(P＜0.05),and the levels of blood oxygen partial pressure(PaO2)and oxygenation index(OI)in the Chinese medicine group were obviously higher(P＜0.05);the symp-tom disappearance time and hospitalization time in the two groups were obviously shortened(P＜0.05),and the Chinese medicine group were shorter than the conventional group(P＜0.05);the levels of tumor necrosis factor-α(TNF-α),Interleukin 6(IL-6),CD3+,CD4+,and CD8+in the two groups were obviously lower(P＜0.05),and the declines were greater in the Chinese medicine group(P＜0.05);the levels of endotoxin(ET),di Diamine oxidase(DAO)and D-lactic acid in the two groups were obviously lower than those before treatment(P＜0.05),and the improvements of intestinal mucosal barrier function indicators in the Chinese medicine group were higher(P＜0.05).Conclusion:The treatment of SAP combined with lung injury using Western medicine and Dachengqi decoction nasal feeding has an ideal effect and high clinical application value.
Severe acute pancreatitisLung injuryDachengqi decoctionOxygenation indexIntestinal mucosal barrier function
国家科技期刊平台
NSTL
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