摘要
目的:探讨麻防犀角地黄汤治疗寒包火型银屑病(Ps)的临床疗效.方法:选取2021年1月～2022年7月桐城市中医医院收治的60例寒包火型Ps患者,采用随机数字表法分为观察组和对照组各30例.两组均外用卡泊三醇软膏,对照组口服阿维A胶囊,观察组服用麻防犀角地黄汤,疗程均为8周.比较两组疗效和治疗前后中医症候积分、面积与严重性指数(PASI)评分、皮肤病生活质量指数(DLQI)评分及白介素-23(IL-23)、白介素-17(IL-17)、CD4+辅助型T1细胞/T2细胞(Th1/Th2),比较两组不良反应发生率和随访6个月复发率.结果:观察组有效率为70.00％,与对照组的83.33％无显著差异(P＜0.05);治疗后,观察组病程迁延、秋冬疕重、受寒疕重中医证候积分和 PASI 评分、DLQI 评分分别为(3.60±0.75)分、(3.24±0.76)分、(3.29±0.22)分、(28.12±4.95)分和(11.52±1.82)分,低于对照组的(4.49±0.87)分、(4.01±0.78)分、(3.54±0.30)分、(33.25±5.09)分和(13.97±2.03)分(P＜0.05);观察组 IL-23、IL-17 水平为(2.25±0.37)pg/mL 和(7.13±1.19)pg/mL,低于对照组(3.43±0.51)pg/mL 和(9.04±1.36)pg/mL,Th1/Th2 为(4.91±0.79),高于对照组(3.52±0.58)(P＜0.05);观察组复发率为16.67％,低于对照组的43.33％(P＜0.05).结论:麻防犀角地黄汤治疗寒包火型Ps疗效确切,可降低复发率.
Abstract
Objective To explore the clinical curative effect of Mafang Xijiao Dihuang Decoction on psoriasis(Ps)of cold-enveloping-fire syndrome.Methods A total of 60patients with Ps of cold-enveloping-fire syndrome admitted to Tongcheng tradi-tional Chinese medicine hospital were enrolled between January 2021 and July 2022.According to random number table method,they were divided into observation group and control group,30cases in each group.After topical calcipotriol ointment in both groups,control group was given oral acitretin capsules,while observation group was given Mafang Xijiao Dihuang Decoction for 8weeks.The curative effect,scores of TCM syndromes,psoriasis area and severity index(PASI)and dermatology life quality in-dex(DLQI),levels of interleukin-23(IL-23),interleukin-17(IL-17)and CD4+helper T1cells/T2cells(Th1/Th2)before and after treatment,incidence of adverse reactions and recurrence rate within 6months of follow-up were compared between the two groups.Results The difference in response rate between observation group and control group was not statistically significant(70.00％vs 83.33％,P＜0.05).After treatment,scores of TCM syndromes(prolonged disease course,severe head sore in au-tumn and winter,cold-induced head sore),PASI and DLQI in observation group were(3.60±0.75)points,(3.24±0.76)points,(3.29±0.22)points,(28.12±4.95)points and(11.52±1.82)points,lower than those in control group[(4.49± 0.87)points,(4.01±0.78)points,(3.54±0.30)points,(33.25±5.09)points,(13.97±2.03)points,P＜0.05].The lev-els of IL-23and IL-17in observation group were(2.25±0.37)pg/mL and(7.13±1.19)pg/mL,lower than those in control group[(3.43±0.51)pg/mL,(9.04±1.36)pg/mL],while Th1/Th2was higher than that in control group[(4.91±0.79)vs(3.52±0.58),P＜0.05].The recurrence rate in observation group was lower than that in control group(16.67％vs 43.33％,P＜0.05).Conclusion The curative effect of Mafang Xijiao Dihuang Decoction is significant on Ps of cold-enveloping-fire syn-drome,which can reduce recurrence rate.
基金项目
安徽省高等学校协同创新项目(GXXT-2020-064)
国家科技期刊平台
NSTL
万方数据