Changes and clinical significance of miR-21and miR-1221evels in peripheral blood of patients with gastric cancer of different TCM syndromes types
Objective:To observe the changes and clinical significance of peripheral blood miR-21and miR-122levels in patients with gastric cancer(GC)of different TCM syndromes types.[Methods]100patients with GC admitted to our hospital were selected as the research subjects from January 2022to January 2023.According to the clinical manifestations and signs,the patients were classified by TCM syndromes types.The levels of peripheral blood miR-21and miR-122,incidence rates of toxic and side effects and survival after half a year of chemotherapy were compared among GC patients with different TCM syndromes types.[Results]Among the 100patients with GC,there were 47cases of spleen-stomach damp-heat syndrome,17cases of spleen-stomach deficiency-cold syndrome,15cases of liver-stomach disharmony syndrome,13cases of blood stasis internal bloc-king syndrome and 8cases were phlegm-turbidity stagnation syndrome.The level of miR-21in peripheral blood of GC patients with different TCM syndromes types was shown as spleen-stomach damp-heat syndrome＞spleen-stomach deficiency-cold syndrome＞liver-stomach disharmony syndrome＞blood stasis internal blocking syndrome＞phlegm-turbidity stagnation syndrome,while the level of miR-122was manifested as spleen-stomach damp-heat syndrome＜spleen-stomach deficiency-cold syndrome＜liver-stomach disharmony syndrome＜blood stasis internal blocking syndrome＜phlegm-turbidity stagnation syndrome(P＜0.05).The incidence rates of gastrointestinal reaction and bone marrow suppression in patients with spleen-stomach damp-heat syndrome were significantly higher than those in patients with phlegm-turbidity stagnation syndrome and blood stasis internal blocking syn-drome(P＜0.05),and the incidence rates of nervous system reaction and renal damage were significantly higher than those in pa-tients with blood stasis internal blocking syndrome(P＜0.05).The incidence rate of bone marrow suppression was significantly higher in patients with spleen-stomach deficiency-cold syndrome than that in patients with phlegm-turbidity stagnation syndrome and blood stasis internal blocking syndrome(P＜0.05),and the incidence rate of nervous system reaction was also significantly higher than that in patients with blood stasis internal blocking syndrome(P＜0.05).The incidence rate of nervous system reaction was significantly higher in patients with liver-stomach disharmony syndrome than that in patients with blood stasis internal bloc-king syndrome(P＜0.05).The survival rate of GC patients with different TCM syndromes types after 6months of follow-up after chemotherapy revealed spleen-stomach damp-heat syndrome＜spleen-stomach deficiency-cold syndrome＜liver-stomach dis-harmony syndrome＜blood stasis internal blocking syndrome＜phlegm-turbidity stagnation syndrome,but there was no significant difference between the groups(P＞0.05).[Conclusion]There are differences in the expressions of miR-21and miR-122in pe-ripheral blood of GC patients with different TCM syndromes types.The detection of the two levels has certain value on evaluating the disease progression and prognosis of patients.
Gastric cancerTCM syndromes typesmiR-21miR-122ChemotherapyToxic and side effectsPrognosis
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