The therapeutic effect of Wenyang Yiqi Lishui Huoxue Formula Combined with sakubatrevalsartan on patients with chronic heart failure and its effect on the levels of CD40L and Hcy
Objective:To explore the effect of Wenyang Yiqi Lishui Huoxue Formula Combined with Sa Ku Ba Qu Xie Sha Tan on serum soluble CD40L(CD40L)and homocysteine(Hcy)levels in patients with chronic heart failure.Methods:100patients with chronic heart failure admitted to our hospital from June 2020to June 2022were randomly selected and divided into control group and combined group with 50cases each according to the complete randomized method.The control group was treated with Sa Ku Ba Qu Xie Sha Tan,and the combined group was treated with Sa Ku Ba Qu Xie Sha Tan and Wenyang Yiqi Lishui Huoxue Formula.The heart function,CD40L,Hey,BNP level,quality of life,severity of clinical symptoms,TCM syndrome changes and clinical efficacy were evaluated.Results:The level of lvrdd,lvpwd and IVS in the combined group was lower than that in the control group,and the level of LVEF was higher than that in the control group(P＜0.05).The levels of CD40L,Hcy and BNP in the combined group were lower than those in the control group(P＜0.05).The scores of heart failure and quality of life in the combined group were lower than those in the control group(P＜0.05).The TCM syndrome score of the combined group was lower than that of the control group(P＜0.05).The total effective rate of the combined group was higher than that of the con-trol group(P＜0.05).Conclusion:The combination of Wenyang Yiqi Lishui Huoxue Recipe and Sa Ku Ba Qu Xie Sha Tan can significantly improve the clinical symptoms,improve the abnormal expression of CD40L and Hcy,and promote the recovery of heart function.
Wenyang Yiqi Lishui Huoxue FormulaSa Ku Ba Qu Xie Sha TanChronic heart failureSoluble CD40LHo-mocysteine
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