Effect evaluation of invigorating spleen and tonifying kidney on early and middle ankylosing spondylitis
Objective:To evaluate the effect of invigorating spleen and tonifying kidney on early and middle ankylosing spon-dylitis.Methods:87patients with ankylosing spondylitis treated in our hospital from March 2020to April 2021were divided into ob-servation group and control group by double-blind sampling method.The control group was treated with Western medicine,while the observation group was treated with the method of strengthening the spleen,tonifying the kidney,and strengthening the Du me-ridian.Comparing the TCM syndrome scores of the two groups,Enzyme-linked immunosorbent assay determination of endothelin-1(ET-1),macrophage mobility inhibitory factor(MIF),interleukin 1β(IL-1β),interleukin 17(IL-17),prostaglandin E2(PGE2),pain media pro-cyclooxygenase-2(COX-2)level,Comparing the efficacy and the incidence of adverse effects be-tween the two groups.Results:After treatment,neck stiffness pain,lumbosacral hip stiffness,ET-1,COX-2and PGE2 were lower than before treatment(P＜0.05);SPARCC score decreased after treatment(P＜0.05);but SSS score difference was not obvious,no statistical difference(P＞0.05);The levels of IL-17,MIF and IL-1β after treatment were lower than those before treatment(P＜0.05).Compared with the control group,the effective rate of the observation group was higher(73.81％VS 93.33％)(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(21.43％VS 4.44％)(P＜0.05).Conclusion:Treat patients with early and middle term ankylosing spondylitis with tonifying kidney and strengthening supervision method,which can help to relieve the inflammatory reaction in the body,with better curative effect and higher safety.
国家科技期刊平台
NSTL
万方数据
