Effect of jiawei bufei na qi decoction on lung function and serum inflammatory factor level in patients with acute ex-acerbation of COPD
Objective To investigate the effect of jiawei bufei na qi decoction on lung function and serum inflammatory factors in patients with chronic obstructive pulmonary disease(COPD)during acute exacerbation.Methods A total of 58patients with a-cute exacerbation of COPD admitted to our hospital from February 2017to February 2019were selected as the study objects,and they were divided into the combined group and the conventional group by random number method,with 29patients.The routine group received routine treatment after admission,including acid-base balance and water electrolyte correction,oral anticholine,anti-infection drugs,etc.The combined group was treated with jiawei bufei nanqi decoction on the basis of the conventional group.Compare the clinical efficacy and lung function indexes[forced vital capacity(English abbreviation,FVC),forced expir-atory volume(English abbreviation,FEV1),maximum expiratory flow rate(English abbreviation,PEF)]and CAT scores of the two groups before and after treatment.Comparison of serum inflammatory factors[tumor necrosis factor-α(English abbrevia-tion,TNF-α),C-reactive protein(English abbreviation,CRP),interleukin-6(English abbreviation,IL-6),pre-and post-treatment Calcitonin(English abbreviation,PCT)]and respiratory mechanics indicators[peak air pressure(English abbrevia-tion,PIP),respiratory work(English abbreviation,WOB),airway resistance(English abbreviation,Raw),dynamic compli-ance(Cdyn)]difference,and finally calculated the incidence of adverse reactions in the two groups of patients.ResultsThe to-tal effective rate of the combined group after treatment was 93.10％,which was significantly higher than that of the conventional group,68.97％(P＜0.05).After treatment,the FVC in the combination group was significantly higher than that before the treat-ment and after the conventional group(P＜0.05);the CAT score after the combination group was significantly lower than that be-fore the treatment and after the conventional group(P＜0.05);FEV1 and PEF were significantly increased in the two groups be-fore and after treatment(P＜0.05);there was no significant difference between the two groups before and after FEVland PEF treatment(P＞0.05).The TNF-α,CRP and IL-6in the combination group were significantly lower than those before treatment and after treatment in the conventional group(P＜0.05);PCT was significantly lower in the two groups before and after treatment(P＜0.05);there was no significant difference between the two groups before and after PCT treatment(P＞0.05).The PIP,WOB,and Raw after the combination group were significantly lower than those before the treatment and after the conventional group(P＜0.05).The Cdyn after the combination group was significantly higher than that before the treatment and after the con-ventional group,and the differences were statistically significant.Significance(P＜0.05).The total incidence of adverse reactions in the combination group was 17.24％compared with 10.34％in the conventional group(P＞0.05).ConclusionIn the treatment of patients with acute exacerbation of COPD,jiawei bufei naqi decoction can improve the treatment effect,enhance lung function,reduce inflammation level,improve respiratory mechanics indicators,and will not increase the total incidence of adverse reac-tions,which has certain clinical application value.
Modified Bufei Naqi DecoctionChronic Obstructive Pulmonary DiseaseRespirationLung Function
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