Clinical observation of Huayu Tongmai Decoction combined with rt-PA intravenous thrombolysis in treatment of cerebral apoplexy with Qi deficiency and blood stasis syndrome
Objective To investigate the clinical effect of Huayu Tongmai Decoction combined with rt-PA intravenous throm-bolytic therapy on stroke caused by Qi deficiency and blood stasis.Methods 100stroke patients with Qi-deficiency and blood-sta-sis syndrome admitted to Liaocheng People's Hospital from September 2019to September 2023(please add the name of the unit)were selected as the study objects,and were divided into 61 cases in the study group and 39cases in the control group according to the treatment methods.The study group was treated with Huayu Tongmai Decoction combined with rt-PA intravenous thrombolytic therapy,and the control group was treated with rt-PA intravenous thrombolytic therapy.The clinical symptom score,coagulation status,cerebral hemodynamics and serum marker levels were compared between the two groups.Results After treatment,the score of National Institutes of Health Stroke Scale(NIHSS)in the study group was lower than that in the control group,and the score of Stroke Impact Scale(SIS)and Berg Balance Scale(BBS)was higher than that in the control group(P＜0.05).After treat-ment,the coagulation time(KT)and coagulation reaction time(RT)of the study group were higher than those of the control group,and the maximum amplitude(MA)and coagulation Angle(α)of the study group were lower than those of the control group(P＜0.05).After treatment,the average cerebral arterial blood flow velocity(Vm),systolic blood flow velocity(Vs)and end-diastolic blood flow velocity(Vd)of the study group were higher than those of the control group,and the resistance index(RI)was lower than that of the control group(P＜0.05).After treatment the levels of glial fibrinolytic acid protein(GFAP),von Willefibrilia factor(vWF)and vascular cell adhesion molecule(VCAM-1)of the study group were lower than those of the control group(P＜O.05).Conclusion Huayu Tongmai Decoction combined with rt-PA intravenous thrombolytic therapy for stroke syndrome of Qi deficiency and blood stasis can reduce nerve function injury,improve daily activity ability,improve coagulation status,increase cerebral blood perfusion and reduce neuroinflammation.
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