首页|牵正散合活血通络汤治疗脑梗死恢复期风痰瘀阻证患者疗效及神经功能缺损的影响

牵正散合活血通络汤治疗脑梗死恢复期风痰瘀阻证患者疗效及神经功能缺损的影响

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目的:探讨牵正散合活血通络汤对治疗脑梗死恢复期风痰瘀阻证患者疗效及神经功能缺损的影响.方法:选取2022年5月~2023年4月在我院就诊的脑梗死恢复期的患者106例,采用随机数字表法将患者分成对照组和观察组,各53例.对照组给予常规西药治疗,观察组在对照组的基础上采用牵正散合活血通络汤治疗,两组均持续治疗12周.比较两组中医症候积分、临床疗效、神经功能缺损情况和日常生活能力[美国国立卫生院卒中量表(NIHSS)和改良Barthel指数(MBI)量表]、血液流变学参数及安全性.结果:治疗后,2组主症、次症及总分较治疗前降低,观察组更低(P<0.05).观察组临床总有效率高于对照组(88.68%vs.71.70%,P<0.05).治疗后,两组NIHSS评分降低,MBI评分升高(P<0.05),与对照组相比,观察组NIHSS评分更低,MBI评分则更高(P<0.05).与治疗前相比,治疗后2组低切全血黏度、红细胞比容及纤维蛋白原水平均下降(P<0.05),观察组上述血液流变学参数较对照组均下降(P<0.05).两组不良反应总发生率比较(对照组7.55%vs.观察组1.89%),差异无统计学意义(P>0.05).结论:脑梗死恢复期风痰瘀阻证患者运用牵正散合活血通络汤治疗可缓解临床症状,提高疗效,促进神经功能修复,提升日常生活能力,改善血液流变学,且不增加不良反应.
Effect of Qianzheng powder combined with Huoxuetongluo Decoction on patients with syndrome of blockade of wind-phlegm-static blood of cerebral infarction in convalescent period and nerve function defect
Objective:To investigate the effect of Qianzheng powder combined with Huoxuetongluo Decoction on the treat-ment of syndrome of blockade of wind-phlegm-static blood of cerebral infarction in convalescence and nerve function defect.Methods:106patients with cerebral infarction in our hospital from May 2022to April 2023were selected and divided into control group and observation group by random number table method,with 53patients in each group.The control group was treated with conventional westem medicine,and the observation group was treated with Zhuzheng SAN combined with Huoxue Tongluo Decoc-tion on the basis of the control group.Both groups were treated for 12weeks.Traditional Chinese medicine syndrome score,clinical efficacy,neurological impairment,ability of daily living(NIHSS and MBI),hemorheological parameters and safety were com-pared between the two groups.Results:Aftertreatment,the main disease,secondary disease and total score were lower in 2groups than before treatment,and lower in observation group(P<0.05).The total clinical effective rate of the observation group was higher than that of the control group(88.68%vs.71.70%,P<0.05).After treatment,NIHSS score decreased and MBI score increased in both groups(P<0.05).Compared with the control group,NIHSS score was lower in the observation group,and MBI score was higher(P<0.05).Compared with before treatment,the whole blood viscosity,erythrocyte volume and fibrinogen water in the 2groups after treatment were decreased on average(P<0.05),and the above hemorheological parameters in the ob-servation group were decreased compared with the control group(P<0.05).There was no significant difference in the total inci-dence of adverse reactions between the two groups(control group 7.55%vs.observation group 1.89%)(P>0.05).Conclusion:In patients with syndrome of blockade of wind-phlegm-static blood of cerebral infarction during recovery period,the treatment of Qianzheng powder combined with Huoxuetongluo Decoction can alleviate clinical symptoms,improve curative effect,promote nerve function repair,enhance daily living ability,improve hemorheology,and do not increase adverse reactions.

Cerebral infarction convalescence periodSyndrome of blockade of wind-phlegm-static bloodQianzheng pow-der combined with Huoxuetongluo DecoctionNeurological impairment

陈军、何春慧、戴其军

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扬州大学医学院海安临床学院康复科,江苏海安 226600

扬州大学医学院海安临床学院药学部,江苏海安 226600

扬州大学医学院海安临床学院神经内科,江苏海安 226600

脑梗死恢复期 风痰瘀阻证 牵正散合活血通络汤 神经功能缺损

江苏省重大神经精神疾病研究重点实验室开放基金

KJS2029

2024

四川中医
四川省中医药学会,四川省中西医结合学会,四川省针灸学会,四川省中医药科学院

四川中医

CSTPCD
影响因子:0.522
ISSN:1000-3649
年,卷(期):2024.42(5)
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