Study on the clinical application value of Tiaoshen Yizhi Decoction,Tomoxetine combined with biofeedback in school-age children with attention deficit hyperactivity disorder
To explore the clinical application value of Tiaoshen Yizhi Decoction,Combination of Tomoxetine and Biofeed-back in Children with Attention Deficit Hyperactivity Disorder(ADHD).Ninety-six school-age children with ADHD admitted to the Rehabilitation Medical Department of Qinhuangdao Military Industry Hospital from July 2019to September 2022were randomly divided into two groups with 48cases each.The control group was treated with Tomoxetine combined with biofeedback,while the observation group was treated with Tiaoshen Yizhi Decoction on the basis of the control group.The clinical efficacy,the degree of behavioral rehabilitation before and after treatment(Swanson child behavior checklist(SNAP-Ⅳ),the Parental Symptom Questionnaire(PSQ),the neurotransmitter factors(norepinephrine(NE),dopamine(DA),corticosterone(Cor))and ad-verse reactions were compared between the two groups.Compared with the control group(77.08％),the clinical efficacy was higher(95.83％)(P＜0.05).There was no significant difference in SNAP-Ⅳ、PSQ、NE、DA、Cor before treatment(P＞0.05).After treatment,SNAP-Ⅳ(13.45.±4.25)and PSQ score(19.54±5.21)in the observation group were lower than those in the control group(18.12±4.32)and(24.32±5.68),while the levels of NE(19.84±2.89)ng/mL,DA(6.94±1.53)ng/mL,and Cor(374.56±54.29)nmol/L were significantly higher than those in the control group(17.44±2.35)ng/mL,(6.34±1.28)ng/mL(345.68±51.25)nmol/L(P＜0.05).The incidence rates of adverse reactions(fatigue,gastroin-testinal discomfort,and decreased appetite)between the two groups were 8.33％and 12.50％,respectively,with no statistically significant difference(P＞0.05).Tiaoshen Yizhi Decoction,Tomoxetine combined with biofeedback have significant effects on school-age children with ADHD,which can effectively improve neurotransmitters and children's behavior,and have high safety.
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