Study on the correlation between TCM syndrome differentiation and the level of pANCA,IL-23and the severity of ulcerative colitis
Objective To explore the correlation between TCM syndrome differentiation and the levels of serum perinuclear anti-neutrophilic antibody(pANCA)and interleukin-23(IL-23)and the severity of ulcerative colitis.Methods 278patients with ulcerative colitis admitted to our hospital from January 2021to June 2023were retrospectively selected as the study objects,the clinical data of the patients were analyzed,and the included patients were classified by TCM syndrome differentiation.pANCA and IL-23levels were collected from all patients.Mayo activity scale was used to evaluate the severity of disease.Single factor a-nalysis and Pearson correlation analysis were used for statistical analysis.Results Among 278patients with ulcerative colitis,there were 131cases(47.12％)of large intestine damp-heat syndrome,99cases(35.61％)of spleen and kidney Yang deficiency syn-drome,and 48cases(17.27％)of blood stasis and intestinal collateral syndrome.The Mayo activity score,serum pANCA and IL-23levels of the three TCM syndrome differentiation types were compared,and the differences were statistically significant(P＜0.05).According to the Mayo activity score,the patients were divided into three types of disease severity:mild active stage,moderate active stage and severe active stage.A total of 116cases were mildly active stage,96cases were moderately active stage and 66cases were severely active stage.The mild active stage was dominated by spleen-kidney Yang deficiency syndrome,the moderate active stage was dominated by large intestine damp-heat syndrome(P＜0.05),and the number of cases in severe ac-tive stage was not significantly different(P＞0.05).Pearson correlation analysis showed that serum pANCA and IL-23levels were positively correlated with Mayo activity score(P＜0.05).Conclusion There is a certain relationship between TCM syndrome dif-ferentiation and serum pANCA,IL-23level and disease severity.The TCM syndrome differentiation and classification of ulcerative colitis patients can be judged clinically according to serum pANCA,IL-23level and disease severity.
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